Computational Analysis of Gly482Ser Single-Nucleotide Polymorphism in PPARGC1A Gene Associated with CAD, NAFLD, T2DM, Obesity, Hypertension, and Metabolic Diseases

Table 1

SNP tools for the stability prediction of the Gly482Ser variant with DDG.

Computational algorithms	Prediction
I-Mutant2.0; DGG (kcal/mol)	Decreases stability; -0.83
MUpro; DGG (kcal/mol)	Decreases stability; -0.32
DUET; DGG (kcal/mol)	Destabilizing; -0.99
DGG (kcal/mol); DynaMut	Destabilizing; -0.84
mCSM; DGG (kcal/mol)	Destabilizing; -0.99
SDM; DGG (kcal/mol)	Destabilizing; -3.33
CUPSAT; PANTHER	Destabilizing; Probably damaging