PPARγ Plays an Important Role in Acute Hepatic Ischemia-Reperfusion Injury via AMPK/mTOR Pathway

Figure 6

The underlying mechanism of PPARγ in IR injury. Notes: activated PPARγ in IR promoted AMPK phosphorylation and inhibited the phosphorylated form of mTOR, which contributed to the suppression of autophagy in mouse livers. And thus, PPARγ exhibited its protective effects in the hepatic IR injury.