Pathologic and Radiologic Correlation of Adult Cystic Lung Disease: A Comprehensive Review

Figure 5

Pulmonary Langerhans cell histiocytosis. HRCT axial view (a) demonstrating a nodular phase of PLCH with multiple bronchiolocentric variable-sized nodules. The nodules correspond to granulomas on histology (b) showing high power view of Langerhans histiocytic cell aggregates surrounded by lymphocytes, eosinophils, and plasma cells (magnification ×400). Nodular phase eventually evolves to a cystic phase. Axial (c) and coronal (d) views demonstrating multiple subcentimeter lung cysts with thickened and irregular walls. Coronal view shows predominance of these lesions in the upper lobes, with relative sparing of the lung bases.

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