Glioblastoma Stem Cells Microenvironment: The Paracrine Roles of the Niche in Drug and Radioresistance

Figure 2

Schematic representation of interactions between glioma stem cells and components of microenvironment. Blue arrows indicate a positive regulation in terms of proliferation and/or radioresistance. EC, endothelial cells. SC, stromal cells. GSC, glioma stem cells. bFGF, basic Fibroblast Growth Factor. BM, basement membrane. ECM, extracellular matrix. HS, Heparin Sulphate. IL-8, interleukin-8. SDF-1, stromal cell-derived factor-1.