Research Article
Factors Associated with Longitudinal Changes in Mammographic Density in a Multiethnic Breast Screening Cohort of Postmenopausal Women
Table 1
Baseline characteristics and longitudinal BI-RADS density changes in the study cohort by baseline BI-RADS density category (n = 3392).
| | | A (N = 405) | B (N = 1352) | C (N = 1304) | D (N = 331) | Total (N = 3392) | value |
| | Age at baseline | | | | | | <0.001 | | Mean (SD) | 63.0 (8.8) | 62.6 (8.7) | 60.2 (8.6) | 58.4 (8.2) | 61.3 (8.8) | | | Range | 39–86 | 34–92 | 36–87 | 33–81 | 33–92 | | | Race/ethnicity | | | | | | <0.001 | | Non-Hispanic White | 213 (52.6%) | 692 (51.2%) | 693 (53.1%) | 189 (57.1%) | 1787 (52.7%) | | | Hispanic | 125 (30.9%) | 379 (28.0%) | 254 (19.5%) | 38 (11.5%) | 796 (23.5%) | | | Non-Hispanic Asian | 32 (7.9%) | 213 (15.8%) | 296 (22.7%) | 96 (29.0%) | 637 (18.8%) | | | Non-Hispanic other/unknown | 35 (8.6%) | 68 (5.0%) | 61 (4.7%) | 8 (2.4%) | 172 (5.1%) | | | Menarche age | | | | | | <0.001 | | <12 | 110 (27.6%) | 254 (19.0%) | 194 (15.1%) | 36 (11.0%) | 594 (17.7%) | | | 12 to 13 | 207 (51.5%) | 675 (48.8%) | 689 (50.8%) | 179 (53.0%) | 1750 (50.3%) | | | >14 | 85 (21.3%) | 421 (31.4%) | 446 (34.7%) | 104 (31.9%) | 1056 (31.5%) | | | Parity | | | | | | <0.001 | | No | 64 (15.8%) | 202 (15.0%) | 282 (21.8%) | 88 (26.6%) | 636 (18.8%) | | | Yes | 341 (84.2%) | 1148 (85.0%) | 1014 (78.2%) | 243 (73.4%) | 2746 (81.2%) | | | Age at first birth | | | | | | <0.001 | | <20 | 75 (22.1%) | 214 (18.7%) | 102 (10.1%) | 23 (9.5%) | 414 (15.1%) | | | 20 to 30 | 202 (59.4%) | 735 (64.4%) | 679 (67.0%) | 125 (51.4%) | 1741 (63.6%) | | | >30 | 63 (18.5%) | 193 (16.9%) | 232 (22.9%) | 95 (39.1%) | 583 (21.3%) | | | Menopause age | | | | | | 0.897 | | <55 | 356 (87.9%) | 1179 (87.3%) | 1139 (87.6%) | 293 (88.8%) | 2967 (87.6%) | | | 55 and older | 49 (12.1%) | 172 (12.7%) | 161 (12.4%) | 37 (11.2%) | 419 (12.4%) | | | Years since menopause | | | | | | <0.001 | | Less than 5 | 54 (13.4%) | 233 (17.3%) | 326 (25.2%) | 103 (31.5%) | 716 (21.2%) | | | 5 or more | 348 (86.6%) | 1115 (82.7%) | 969 (74.8%) | 224 (68.5%) | 2656 (78.8%) | | | Current hormone use | | | | | | <0.001 | | No | 366 (90.4%) | 1181 (87.4%) | 1037 (79.5%) | 266 (80.4%) | 2850 (84.0%) | | | Yes | 39 (9.6%) | 171 (12.6%) | 267 (20.5%) | 65 (19.6%) | 542 (16.0%) | | | BMI category (race-specific) | | | | | | <0.001 | | Not overweight/obese | 56 (14.1%) | 458 (34.4%) | 679 (53.0%) | 260 (79.8%) | 1453 (43.6%) | | | Overweight | 110 (27.8%) | 492 (37.0%) | 414 (32.3%) | 52 (16.0%) | 1068 (32.0%) | | | Obese | 230 (58.1%) | 381 (28.6%) | 189 (14.7%) | 14 (4.3%) | 814 (24.4%) | | | Smoking | | | | | | 0.025 | | Never | 176 (69.0%) | 670 (75.1%) | 764 (79.3%) | 192 (78.4%) | 1802 (76.5%) | | | Former | 63 (24.7%) | 184 (20.6%) | 163 (16.9%) | 41 (16.7%) | 451 (19.1%) | | | Current | 16 (6.3%) | 38 (4.3%) | 37 (3.8%) | 12 (4.9%) | 103 (4.4%) | | | Physical activity | | | | | | <0.001 | | None | 78 (49.4%) | 236 (41.3%) | 188 (32.5%) | 34 (25.2%) | 536 (37.2%) | | | <150 min mild, moderate, or strenuous activity per week | 45 (28.5%) | 170 (29.8%) | 184 (31.8%) | 45 (33.3%) | 444 (30.8%) | | | At least 150 min mild, moderate, or strenuous activity per week | 35 (22.2%) | 165 (28.9%) | 206 (35.6%) | 56 (41.5%) | 462 (32.0%) | | | Alcohol consumption | | | | | | <0.001 | | Yes | 166 (41.2%) | 623 (46.4%) | 698 (53.9%) | 192 (58.0%) | 1679 (49.8%) | | | No | 237 (58.8%) | 719 (53.6%) | 596 (46.1%) | 139 (42.0%) | 1691 (50.2%) | | | Density change | | | | | | <0.001 | | Decrease | 0 (0.0%) | 47 (3.5%) | 143 (11.0%) | 78 (23.6%) | 268 (7.9%) | | | Increase | 68 (16.8%) | 93 (6.9%) | 66 (5.1%) | 0 (0.0%) | 227 (6.7%) | | | No change | 337 (83.2%) | 1212 (89.6%) | 1095 (84.0%) | 253 (76.4%) | 2897 (85.4%) | |
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