The Effect of Adjuvant Radiotherapy on One- and Two-Stage Prosthetic Breast Reconstruction and on Autologous Reconstruction: A Multicenter Italian Study among 18 Senonetwork Breast Centres
Table 2
Baseline demographic, clinical characteristics, and treatments of the overall cohort stratified by the surgical procedure.
Variable
Overall cohort (3,119 pts)
Autologous reconstruction (187 pts)
Direct to implant (1,230 pts)
Tissue expander/immediate (1,702 pts)
value†
Age (years; n = 3,102)
49 (43–56)
50 (45–56)
47 (42–54)
50 (44–58)
<0.001
BMI (kg/m2; n = 2,698)
22.9 (20.8–25.3)
25.4 (23.1–28.0)
22.0 (20.2–24.0)
23.4 (21.1–26.2)
<0.001
≥30
163 (6.0)
20 (11.8)
28 (2.5)
115 (8.3)
<0.001
Smoking (n = 3,077)
Smokers
447 (14.5)
18 (10.1)
184 (15.3)
245 (14.4)
Ex-smokers
372 (12.1)
18 (10.1)
144 (12.0)
210 (12.4)
0.32
Nonsmokers
2,258 (73.4)
142 (79.8)
874 (72.7)
1,242 (73.2)
Diabetes mellitus (n = 3,086)
102 (3.3)
6 (3.2)
34 (2.8)
62 (3.6)
0.49
Other autoimmune disorders (n = 3,119)
229 (7.3)
14 (7.5)
112 (9.1)
103 (6.1)
0.007
Chemotherapy (n = 3,115)
No
1,213 (38.9)
45 (24.1)
485 (39.6)
683 (40.1)
Adjuvant
1,273 (40.9)
99 (52.9)
447 (36.4)
727 (42.7)
<0.001
Neoadjuvant
616 (19.8)
43 (23.0)
294 (24.0)
279 (16.4)
Adjuvant and neoadjuvant
13 (0.4)
0 (0.0)
0 (0.0)
13 (0.8)
Axillary dissection (n = 3,112)
1,435 (46.1)
94 (50.3)
504 (41.1)
837 (49.3)
<0.001
Postmastectomy radiotherapy (n = 3,116)
1,167 (37.5)
79 (42.3)
392 (32.0)
696 (40.9)
<0.001
Values are expressed as absolute frequency (percentage) for categorical variables and as median (interquartile range) for continuous variables. †Chi-squared test for categorical variables; Kruskal–Wallis test for continuous variables. Abbreviation: BMI: body mass index.
