The Effect of Adjuvant Radiotherapy on One- and Two-Stage Prosthetic Breast Reconstruction and on Autologous Reconstruction: A Multicenter Italian Study among 18 Senonetwork Breast Centres
Table 4
Multivariable hierarchical logistic regression analyses investigating the association between type of surgical procedure performed and key negative outcomes and complications. Each estimate is adjusted for postmastectomy radiotherapy, age, the BMI, smoking habits, diabetes, other autoimmune diseases, type of chemotherapy, and axillary dissection.
Type of surgical procedure
Failure
Explant
Reintervention
Any complication
Severe complications
Any infection
Change in type of reconstruction
aOR (95% CI)
aOR (95% CI)
aOR (95% CI)
aOR (95% CI)
aOR (95% CI)
aOR (95% CI)
aOR (95% CI)
First model specification1
Autologous reconstruction
Ref.
—
Ref.
—
Ref.
—
Ref.
—
Ref.
—
Ref.
—
Ref.
—
DTI reconstruction
1.75 (0.58–5.27)
0.323
3.80 (1.49–9.63)
0.005
0.11 (0.03–0.43)
0.002
0.81 (0.51–1.28)
0.360
1.11 (0.61–2.02)
0.740
0.60 (0.25–1.41)
0.242
0.12 (0.03–0.49)
0.004
TE/I reconstruction
0.96 (0.32–2.86)
0.940
1.14 (0.44–2.91)
0.792
2.20 (0.59–8.17)
0.240
0.44 (0.27–0.71)
0.001
0.44 (0.24–0.80)
0.008
0.77 (0.32–1.83)
0.552
0.05 (0.10–0.27)
<0.001
Second model specification1
DTI reconstruction
Ref.
—
Ref.
—
Ref.
—
Ref.
—
Ref.
—
Ref.
—
Ref.
—
Autologous reconstruction
0.57 (0.19–1.73)
0.323
0.26 (0.10–0.67)
0.005
9.09 (2.30–35.9)
0.002
1.24 (0.78–1.98)
0.360
0.90 (0.50–1.64)
0.740
1.67 (0.71–3.93)
0.242
8.59 (2.02–36.5)
0.004
TE/I reconstruction
0.55 (0.32–0.94)
0.030
0.30 (0.22–0.41)
<0.001
20.0 (12.1–33.0)
<0.001
0.55 (0.43–0.70)
<0.001
0.39 (0.29–0.53)
<0.001
1.28 (0.74–2.23)
0.378
0.45 (0.16–1.26)
0.129
Third model specification1
TE/I reconstruction
Ref.
—
Ref.
—
Ref.
—
Ref.
—
Ref.
—
Ref.
—
Ref.
—
Autologous reconstruction
1.04 (0.35–3.11)
0.940
0.88 (0.34–2.25)
0.792
0.45 (0.12–1.69)
0.240
2.27 (1.41–3.67)
0.001
2.29 (1.24–4.23)
0.008
1.30 (0.55–3.08)
0.552
19.1 (3.75–97.6)
<0.001
DTI reconstruction
1.82 (1.06–3.12)
0.030
3.34 (2.46–4.54)
<0.001
0.05 (0.03–0.08)
<0.001
1.83 (1.43–2.34)
<0.001
2.54 (1.88–3.43)
<0.001
0.78 (0.45–1.36)
0.378
2.23 (0.79–6.27)
0.129
1We have specified different baseline levels for the variable indicating the type of surgical procedure performed and have alternatively selected a different group as the one corresponding to the baseline risk. This allowed to show all the formal comparisons across groups. Abbreviations: aOR: adjusted odds ratio; BMI: body mass index; DTI: direct to implant; TE/I: tissue expander/immediate.