The Breast Journal

Research Article

The Effect of Adjuvant Radiotherapy on One- and Two-Stage Prosthetic Breast Reconstruction and on Autologous Reconstruction: A Multicenter Italian Study among 18 Senonetwork Breast Centres

Table 4

Multivariable hierarchical logistic regression analyses investigating the association between type of surgical procedure performed and key negative outcomes and complications. Each estimate is adjusted for postmastectomy radiotherapy, age, the BMI, smoking habits, diabetes, other autoimmune diseases, type of chemotherapy, and axillary dissection.

Type of surgical procedure

Failure

Explant

Reintervention

Any complication

Severe complications

Any infection

Change in type of reconstruction

aOR (95% CI)

First model specification¹

Autologous reconstruction

Ref.

—

Ref.

—

Ref.

—

Ref.

—

Ref.

—

Ref.

—

Ref.

—

DTI reconstruction

1.75 (0.58–5.27)

0.323

3.80 (1.49–9.63)

0.005

0.11 (0.03–0.43)

0.002

0.81 (0.51–1.28)

0.360

1.11 (0.61–2.02)

0.740

0.60 (0.25–1.41)

0.242

0.12 (0.03–0.49)

0.004

TE/I reconstruction

0.96 (0.32–2.86)

0.940

1.14 (0.44–2.91)

0.792

2.20 (0.59–8.17)

0.240

0.44 (0.27–0.71)

0.001

0.44 (0.24–0.80)

0.008

0.77 (0.32–1.83)

0.552

0.05 (0.10–0.27)

<0.001

Second model specification¹

DTI reconstruction

Ref.

—

Ref.

—

Ref.

—

Ref.

—

Ref.

—

Ref.

—

Ref.

—

Autologous reconstruction

0.57 (0.19–1.73)

0.323

0.26 (0.10–0.67)

0.005

9.09 (2.30–35.9)

0.002

1.24 (0.78–1.98)

0.360

0.90 (0.50–1.64)

0.740

1.67 (0.71–3.93)

0.242

8.59 (2.02–36.5)

0.004

TE/I reconstruction

0.55 (0.32–0.94)

0.030

0.30 (0.22–0.41)

<0.001

20.0 (12.1–33.0)

<0.001

0.55 (0.43–0.70)

<0.001

0.39 (0.29–0.53)

<0.001

1.28 (0.74–2.23)

0.378

0.45 (0.16–1.26)

0.129

Third model specification¹

TE/I reconstruction

Ref.

—

Ref.

—

Ref.

—

Ref.

—

Ref.

—

Ref.

—

Ref.

—

Autologous reconstruction

1.04 (0.35–3.11)

0.940

0.88 (0.34–2.25)

0.792

0.45 (0.12–1.69)

0.240

2.27 (1.41–3.67)

0.001

2.29 (1.24–4.23)

0.008

1.30 (0.55–3.08)

0.552

19.1 (3.75–97.6)

<0.001

DTI reconstruction

1.82 (1.06–3.12)

0.030

3.34 (2.46–4.54)

<0.001

0.05 (0.03–0.08)

<0.001

1.83 (1.43–2.34)

<0.001

2.54 (1.88–3.43)

<0.001

0.78 (0.45–1.36)

0.378

2.23 (0.79–6.27)

0.129

¹We have specified different baseline levels for the variable indicating the type of surgical procedure performed and have alternatively selected a different group as the one corresponding to the baseline risk. This allowed to show all the formal comparisons across groups. Abbreviations: aOR: adjusted odds ratio; BMI: body mass index; DTI: direct to implant; TE/I: tissue expander/immediate.