Research Article
Predicting of Ki-67 Expression Level Using Diffusion-Weighted and Synthetic Magnetic Resonance Imaging in Invasive Ductal Breast Cancer
Table 3
Histopathological and imaging findings of tumors and their associations with the quantitative parameters generated from SyMRI and DWI.
| Parameters | Number (%) | Pre-T1(ms) | Pre-T2(ms) | Pre-PD(pu) | Post-T1(ms) | Post-T2(ms) | Post-PD(pu) | ADC (10−3 mm2/s) |
| Shape | Oval/round | 27 | 1750.4 ± 359.4 | 86.4 ± 12.2 | 77.6 ± 15.7 | 704.8 ± 165.0 | 73.2 ± 12.4 | 83..0 ± 16.3 | 0.934 ± 0.169 | Irregular | 70 | 1664.1 ± 386.2 | 83.2 ± 10.2 | 74.4 ± 13.0 | 647.7 ± 145.1 | 69.9 ± 8.9 | 80.0 ± 16.1 | 0.938 ± 0.162 | value | | 0.270 | 0.265 | 0.274 | 0.116 | 0.207 | 0.250 | 0.800 | Margin | Circumscribed | 28 | 1732.4 ± 336.2 | 86.1 ± 12.0 | 76.8 ± 13.7 | 713.5 ± 153.7 | 73.7 ± 12.2 | 79.7 ± 13.3 | 0.908 ± 0.160 | Noncircumscribed | 69 | 1670.2 ± 396.1 | 83.2 ± 10.3 | 74.7 ± 13.9 | 643.4 ± 147.9 | 69.6 ± 8.8 | 81.3 ± 17.2 | 0.949 ± 0.164 | value | | 0.329 | 0.306 | 0.401 | 0.019 | 0.120 | 0.984 | 0.368 | LN metastasis | Positive | 52 | 1663.8 ± 304.9 | 84.6 ± 10.6 | 75.7 ± 13.8 | 675.3 ± 153.4 | 70.8 ± 9.0 | 82.0 ± 15.3 | 0.938 ± 0.169 | Negative | 45 | 1716.2 ± 452.0 | 83.5 ± 11.3 | 74.8 ± 14.0 | 650.1 ± 151.4 | 70.8 ± 11.2 | 79.6 ± 17.2 | 0.936 ± 0.158 | value | | 0.789 | 0.839 | 0.590 | 0.487 | 0.871 | 0.356 | 0.879 | Histologic grade | Grade 1/2 | 80 | 1665.6 ± 349.6 | 83.9 ± 10.9 | 74.9 ± 14.1 | 658.3 ± 151.3 | 70.6 ± 10.5 | 81.7 ± 16.7 | 0.950 ± 0.150 | Grade 3 | 17 | 1794.1 ± 494.4 | 85.0 ± 10.9 | 77.3 ± 12.5 | 688.9 ± 158.4 | 71.8 ± 7.5 | 77.0 ± 13.0 | 0.876 ± 0.209 | value | | 0.306 | 0.736 | 0.729 | 0.448 | 0.468 | 0.370 | 0.06 | ER | Positive | 70 | 1665.9 ± 349.9 | 83.7 ± 11.0 | 75.4 ± 13.7 | 676.3 ± 155.2 | 70.5 ± 10.4 | 81.5 ± 15.5 | 0.916 ± 0.157 | Negative | 27 | 1745.9 ± 448.3 | 84.9 ± 10.7 | 75.1 ± 14.4 | 630.6 ± 141.6 | 71.5 ± 9.2 | 79.2 ± 15.5 | 0.992 ± 0.170 | value | | 0.754 | 0.435 | 0.760 | 0.183 | 0.444 | 0.363 | 0.037 | PR | Positive | 62 | 1705.2 ± 411.7 | 83.8 ± 11.4 | 74.7 ± 14.7 | 670.4 ± 151.5 | 70.2 ± 10.4 | 81.7 ± 17.4 | 0.916 ± 0.157 | Negative | 35 | 1678.5 ± 362.5 | 84.6 ± 9.8 | 76.4 ± 12.0 | 651.6 ± 155.0 | 71.8 ± 9.4 | 79.4 ± 13.9 | 0.975 ± 0.169 | value | | 0.863 | 0.419 | 0.487 | 0.471 | 0.222 | 0.571 | 0.161 | HER2 | Positive | 29 | 1685.7 ± 407.5 | 86.8 ± 11.2 | 75.5 ± 13.9 | 676.2 ± 148.8 | 73.5 ± 11.1 | 79.7 ± 13.8 | 0.945 ± 0.176 | Negative | 68 | 1693.9 ± 308.9 | 82.9 ± 10.6 | 75.2 ± 13.9 | 658.2 ± 154.4 | 69.7 ± 9.4 | 81.4 ± 17.1 | 0.920 ± 0.131 | value | | 0.555 | 0.084 | 0.819 | 0.651 | 0.125 | 0.699 | 0.662 | Ki-67 index | Ki-67 < 30% | 40 | 1516.2 ± 269.6 | 82.5 ± 12.1 | 71.6 ± 15.8 | 623.3 ± 114.4 | 67.9 ± 9.7 | 80.1 ± 17.4 | 0.976 ± 0.150 | Ki-67 ≥ 30% | 57 | 1808.8 ± 399.7 | 85.2 ± 9.8 | 77.9 ± 11.7 | 691.9 ± 169.2 | 72.9 ± 9.8 | 81.4 ± 15.4 | 0.910 ± 0.168 | value | | <0.001 | 0.077 | 0.050 | 0.035 | 0.009 | 0.676 | 0.022 | Molecular subtype | Luminal A-like | 17 | 1499.2 ± 303.9 | 80.9 ± 12.4 | 68.3 ± 15.9 | 599.4 ± 106.8 | 67..5 ± 10.3 | 78.7 ± 20.1 | 0.924 ± 0.140 | Luminal B-like | 54 | 1722.5 ± 346.8 | 84.7 ± 10.3 | 77.0 ± 13.0 | 698.7 ± 160.3 | 71.4 ± 10.2 | 82.1 ± 15.3 | 0.914 ± 0.162 | HER2+ | 13 | 1630.7 ± 340.6 | 84.5 ± 10.7 | 75.2 ± 12.9 | 620.4 ± 94.5 | 70.5 ± 7.8 | 79.4 ± 16.2 | 0.936 ± 0.109 | Triple-negative | 13 | 1849.7 ± 539.9 | 85.1 ± 11.5 | 77.4 ± 14.0 | 645.2 ± 184.2 | 72.8 ± 10.8 | 80.1 ± 15.3 | 1.050 ± 0.209 | p value | | 0.183 | 0.518 | 0.199 | 0.088 | 0.389 | 0.815 | 0.134 |
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SyMRI, synthetic magnetic resonance imaging; ADC, apparent diffusion coefficient; PD, proton density.
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