Predicting of Ki-67 Expression Level Using Diffusion-Weighted and Synthetic Magnetic Resonance Imaging in Invasive Ductal Breast Cancer

Table 3

Histopathological and imaging findings of tumors and their associations with the quantitative parameters generated from SyMRI and DWI.

Parameters	Number (%)	Pre-T1(ms)	Pre-T2(ms)	Pre-PD(pu)	Post-T1(ms)	Post-T2(ms)	Post-PD(pu)	ADC (10^−3 mm^2/s)
Shape
Oval/round	27	1750.4 ± 359.4	86.4 ± 12.2	77.6 ± 15.7	704.8 ± 165.0	73.2 ± 12.4	83..0 ± 16.3	0.934 ± 0.169
Irregular	70	1664.1 ± 386.2	83.2 ± 10.2	74.4 ± 13.0	647.7 ± 145.1	69.9 ± 8.9	80.0 ± 16.1	0.938 ± 0.162
value		0.270	0.265	0.274	0.116	0.207	0.250	0.800
Margin
Circumscribed	28	1732.4 ± 336.2	86.1 ± 12.0	76.8 ± 13.7	713.5 ± 153.7	73.7 ± 12.2	79.7 ± 13.3	0.908 ± 0.160
Noncircumscribed	69	1670.2 ± 396.1	83.2 ± 10.3	74.7 ± 13.9	643.4 ± 147.9	69.6 ± 8.8	81.3 ± 17.2	0.949 ± 0.164
value		0.329	0.306	0.401	0.019	0.120	0.984	0.368
LN metastasis
Positive	52	1663.8 ± 304.9	84.6 ± 10.6	75.7 ± 13.8	675.3 ± 153.4	70.8 ± 9.0	82.0 ± 15.3	0.938 ± 0.169
Negative	45	1716.2 ± 452.0	83.5 ± 11.3	74.8 ± 14.0	650.1 ± 151.4	70.8 ± 11.2	79.6 ± 17.2	0.936 ± 0.158
value		0.789	0.839	0.590	0.487	0.871	0.356	0.879
Histologic grade
Grade 1/2	80	1665.6 ± 349.6	83.9 ± 10.9	74.9 ± 14.1	658.3 ± 151.3	70.6 ± 10.5	81.7 ± 16.7	0.950 ± 0.150
Grade 3	17	1794.1 ± 494.4	85.0 ± 10.9	77.3 ± 12.5	688.9 ± 158.4	71.8 ± 7.5	77.0 ± 13.0	0.876 ± 0.209
value		0.306	0.736	0.729	0.448	0.468	0.370	0.06
ER
Positive	70	1665.9 ± 349.9	83.7 ± 11.0	75.4 ± 13.7	676.3 ± 155.2	70.5 ± 10.4	81.5 ± 15.5	0.916 ± 0.157
Negative	27	1745.9 ± 448.3	84.9 ± 10.7	75.1 ± 14.4	630.6 ± 141.6	71.5 ± 9.2	79.2 ± 15.5	0.992 ± 0.170
value		0.754	0.435	0.760	0.183	0.444	0.363	0.037
PR
Positive	62	1705.2 ± 411.7	83.8 ± 11.4	74.7 ± 14.7	670.4 ± 151.5	70.2 ± 10.4	81.7 ± 17.4	0.916 ± 0.157
Negative	35	1678.5 ± 362.5	84.6 ± 9.8	76.4 ± 12.0	651.6 ± 155.0	71.8 ± 9.4	79.4 ± 13.9	0.975 ± 0.169
value		0.863	0.419	0.487	0.471	0.222	0.571	0.161
HER2
Positive	29	1685.7 ± 407.5	86.8 ± 11.2	75.5 ± 13.9	676.2 ± 148.8	73.5 ± 11.1	79.7 ± 13.8	0.945 ± 0.176
Negative	68	1693.9 ± 308.9	82.9 ± 10.6	75.2 ± 13.9	658.2 ± 154.4	69.7 ± 9.4	81.4 ± 17.1	0.920 ± 0.131
value		0.555	0.084	0.819	0.651	0.125	0.699	0.662
Ki-67 index
Ki-67 < 30%	40	1516.2 ± 269.6	82.5 ± 12.1	71.6 ± 15.8	623.3 ± 114.4	67.9 ± 9.7	80.1 ± 17.4	0.976 ± 0.150
Ki-67 ≥ 30%	57	1808.8 ± 399.7	85.2 ± 9.8	77.9 ± 11.7	691.9 ± 169.2	72.9 ± 9.8	81.4 ± 15.4	0.910 ± 0.168
value		<0.001	0.077	0.050	0.035	0.009	0.676	0.022
Molecular subtype
Luminal A-like	17	1499.2 ± 303.9	80.9 ± 12.4	68.3 ± 15.9	599.4 ± 106.8	67..5 ± 10.3	78.7 ± 20.1	0.924 ± 0.140
Luminal B-like	54	1722.5 ± 346.8	84.7 ± 10.3	77.0 ± 13.0	698.7 ± 160.3	71.4 ± 10.2	82.1 ± 15.3	0.914 ± 0.162
HER2+	13	1630.7 ± 340.6	84.5 ± 10.7	75.2 ± 12.9	620.4 ± 94.5	70.5 ± 7.8	79.4 ± 16.2	0.936 ± 0.109
Triple-negative	13	1849.7 ± 539.9	85.1 ± 11.5	77.4 ± 14.0	645.2 ± 184.2	72.8 ± 10.8	80.1 ± 15.3	1.050 ± 0.209
p value		0.183	0.518	0.199	0.088	0.389	0.815	0.134

SyMRI, synthetic magnetic resonance imaging; ADC, apparent diffusion coefficient; PD, proton density.