Multi-MicroRNA Analysis Can Improve the Diagnostic Performance of Mammography in Determining Breast Cancer Risk

Table 4

Modeling and model validation performance using the general nonlinear model (SVM) and linear model (GLM) analysis.

Method	Biomarkers	AUC	Cutoff value	Training set		Validation set
				Sensitivity (%)	Specificity (%)	Sensitivity (%)			Specificity (%)
						Total	Under 50	Over 50	Total	Under 50	Over 50
SVM	miR-1246, 202, 21, and 219B	0.967	0.522	84.5	85	91.7	100	83.3	88.3	86.7	90.0
GLM	miR-1246, 202, 21, and 219B	0.965	0.523	82.1	85	86.7	93.3	80.0	90.0	93.3	86.7