Determination of Platycodin D and Platycodin D3 in Rat Plasma Using Liquid Chromatography-Tandem Mass Spectrometry

Table 5

Pharmacokinetic parameters of PD and PD3 after intravenous (25 mg/kg) or oral administration of PD (500 mg/kg) to rats (𝑛=4).

Parameter	PD	PD3
Intravenous
AUC (𝜇g·hr mL^−1)	11.42±3.43	1.96±0.50
Terminal half-life (hr)	1.99±0.41	3.55±0.87
MRT (hr)	1.58±0.41	2.85±0.77
𝑉ss (L·kg^−1)	3.59±1.28	35.32±18.69
CL (L·hr^−1 kg^−1)	2.32±0.90	11.84±27.77
Oral
AUC (𝜇g·hr mL^−1)	0.66±0.36	0.53±0.31
Terminal half-life (hr)	6.23±1.84	6.20±1.05
𝐶max (𝜇g·mL^−1)	0.22±0.22	0.20±0.24
𝑇max (hr)^a	0.75 (0.17–3)	0.48 (0.11–1.61)

Data are mean ± SD (standard deviation).
aMedian (ranges).