Elements of the B Cell Signalosome Are Differentially Affected by Mercury Intoxication

Figure 4

Effect of Hg⁺² on stimulation of elements of the BCR signal transduction pathway after stimulation of the BCR with anti-mu (12.5 μg/mL). In Figure 4 the y-axis represents differences in MFI between (BCR stimulated cells treated or not with Hg²⁺) and control cells which have neither been treated with Hg nor stimulated via the BCR. The x-axis represents time after stimulation of the BCR. (a) pERK versus time, (b) pSyk versus time, (c) pBtk versus time, (d) pBLNK versus time, (e) pERK versus pSyk versus time in the absence of Hg⁺², and (f) pERK versus pSyk in the presence of Hg⁺².

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