Selenocysteine, Pyrrolysine, and the Unique Energy Metabolism of Methanogenic Archaea

Table 1

Sec-containing proteins of archaea.

Selenoprotein-containing enzyme	Subunit	Function	Characteristic organism	Reference
Formate dehydrogenase	FdhA	Methanogenesis	Methanococcus vannielii	[23][24]
Formyl-methanofuran dehydrogenase	FwuB	Methanogenesis	Methanopyrus kandleri	[25]
F420-reducing hydrogenase	FruA	Methanogenesis	Methanococcus voltae	[26]
F420-nonreducing hydrogenase	VhuD	Methanogenesis	Methanococcus voltae	[26][27]
	VhuU	Methanogenesis
Heterodisulfide reductase	HdrA	Methanogenesis	Methanocaldococcu 𝑠^a jannaschii	[28]
Selenophosphate synthetase	homomeric	Sec synthesis	Methanococcus maripaludis	[28, 29]
HesB-like protein	unknown	Unknown (iron/sulfur cluster assembly?)	Methanococcus maripaludis	[29, 30]

^a𝑀ethanococcus jannaschii was placed in a separate genus, Methanocaldococcus [31].