Differential Expression of MicroRNAs between Eutopic and Ectopic Endometrium in Ovarian Endometriosis

Table 5

Gene Ontology analysis of the predicted target genes of 50 miRNAs differentially expressed. Onto-Express analysis on predicted targets of the differentially expressed miRNAs identified enrichment for biological process categories. The gene column indicates the number of predicted targets of the differentially expressed miRNAs upon the number of the targets of all miRNAs considered for the study. Significant differences from the number of targets in each GO category with the expected number of genes were calculated with the assumption of a hypergeometric distribution and P-values were adjusted with the false discovery rate (fdr) correction. 𝑃<.05.

Rank	Biological process category	Genes	Corrected 𝑃-value
1	Cellular process	2408/6644	.0
	Cell motion	148/330	.0
	Cell communication	908/2223	.0
	Cellular component organization	546/1383	.0
	Cellular developmental process	400/949	.0
	Cellular metabolic process	1563/4269	.0
	Regulation of cellular process	1555/3840	.0
	Cell development	183/419	.0
	Positive regulation of cellular process	371/875	.0
	Negative regulation of cellular process	394/932	.0
	Cell cycle	223/555	1.0E−5
	Cell death	235/587	2.0E−5
	Cell proliferation	237/602	5.0E−5
	Actin-filament based process	90/197	6.0E−5
	Cell fate commitment	45/83	9.0E−5
	Cell aging	14/21	7.0E−4
	Vescicle-mediated transport	158/397	7.3E−4
	Cell growth	51/112	.00286
	Cell fate determination	15/23	.00286
	Cellular localization	224/609	.00506
	Gene silencing	16/27	.00696
	Cell cycle process	124/323	.00696
	Translational initiation	23/48	.01253
	Cell fate specification	12/20	.01728
	Cellular response to stimulus	110/292	.03290
	Cell adhesion	173/479	.04094
2	Negative regulation of biological process	421/992	.0
	Negative regulation of metabolic process	193/422	.0
	Negative regulation to cellular process	394/932	.0
	Negative regulation of developmental process	129/309	1.9E−4
	Negative regulation of response to stimulus	16/29	.01705
	Negative regulation of growth	24/53	.03564
3	Multicellular organismal process	820/2037	.0
	Multicellular organismal development	675/1606	.0
	Regulation of multicellular organismal process	171/421	2.0E−4
	System process	227/606	.00750
	Respiratory gaseous exchange	11/17	.01639
4	Biological regulation	1656/4148	.0
	Regulation of molecular function	211/478	.0
	Regulation of biological process	1597/3961	.0
	Regulation of biological quality	281/732	1.3E−4
5	Regulation of biological process	1597/3961	.0
	Regulation of metabolic process	850/2038	.0
	Regulation of developmental process	283/657	.0
	Regulation of cellular process	1555/3840	.0
	Positive regulation of cellular process	384/933	.0
	Negative regulation of cellular process	421/992	.0
	Regulation of multicellular organismal process	171/421	1.4E−4
	Regulation of localization	110/261	8.7E−4
	Regulation of locomotion	41/95	.02619
	Regulation of growth	64/164	.04199
6	Metabolic process	1631/4509	.0
	Biosynthetic process	899/2354	.0
	Negative regulation of metabolic process	193/422	.0
	Positive regulation of metabolic process	201/473	.0
	Regulation of metabolic process	1563/2038	.0
	Cellular metabolic process	1563/4269	.0
	Primary metabolic process	1551/4187	.0
	Macromolecule metabolic process	1383/3644	.0
	Oxydation reduction	52/255	5.0E−5
	Catabolic process	237/665	.01317
	Nitrogen compound metabolic process	49/193	.03270
7	Developmental process	821/1967	.0
	Multicellular organismal development	675/1606	.0
	Anatomical structure morphogenesis	310/710	.0
	Embryonic development	140/304	.0
	Anatomical structure development	584/1379	.0
	Cellular developmental process	400/949	.0
	Regulation of developmental process	283/657	.0
	Positive regulation of developmental process	131/295	1.0E−5
	Anatomical structure formation involved in Morphogenesis	97/216	4.0E−5
	Pattern specification process	79/173	1.6E−4
	Negative regulation of developmental process	129/309	1.6E−4
	Pigmentation during development	9/13	.01264
	Reproductive developmental process	31/68	.02708
	Aging	17/36	.04082
8	Positive regulation of biological process	384/933	.0
	Positive regulation of metabolic process	201/473	.0
	Positive regulation of cellular process	371/875	.0
	Positive regulation of developmental process	131/295	1.0E−5
	Positive regulation of homeostatic process	6/8	.03203
9	Localization	715/1953	.0
	Localization of cell	148/330	.0
	Macromolecule localization	247/638	1.1E−4
	Regulation of localization	110/261	7.7E−4
	Cellular localization	224/609	.00422
	Establishment of localization	577/1657	.00463
10	Death	235/591	2.0E−5
	Cell death	235/587	1.0E−5
11	Anatomical structure formation	242/629	1.1E−4
	Anatomical structure formation involved in  Morphogenesis	97/216	3.0E−5
	Cellular component assembly	165/452	.01276
12	Response to stimulus	464/1276	2.4E−4
	Response to chemical stimulus	185/465	5.3E−4
	Response to endogenous stimulus	59/136	.00633
	Negative regulation to response to stimulus	16/29	.01844
	Behavior	84/215	.02638
	Cellular response to stimulus	110/292	.03534
	Response to stress	253/718	.03918
13	Multi-organism process	113/286	.00251
	Interspecies interaction between organisms	71/172	.00565
	Female pregnancy	19/39	.04504
14	Growth	96/235	.00334
	Cell growth	51/112	.00298
	Negative regulation of growth	24/53	.03391
	Regulation of growth	64/164	.03916
15	Locomotion	111/277	.00422
	Cell motility	97/223	3.5E−4
	Regulation of locomotion	41/95	.02439
16	Establishment of localization	577/1657	.00458
	Establishment of protein localization	207/536	3.3E−4
	Establishment of localization in cell	209/576	.01045
17	Reproduction	117/303	.00983
	Reproductive process	116/301	.01127
18	Reproductive process	116/301	.01024
	Reproductive developmental process	31/68	.03090
	Female pregnancy	19/39	.04504
19	Biological adhesion	173/479	.03486
	Cell adhesion	173/479	.03486
20	Rhythmic process	26/59	.04158