BioMed Research International

Research Article

Differential Expression of MicroRNAs between Eutopic and Ectopic Endometrium in Ovarian Endometriosis

Table 7

Genes aberrantly expressed in ovarian and peritoneal endometriosis that are predicted targets of the differentially expressed miRNAs. The miRNAs predicted to regulate the expression of the genes known to be aberrantly up- ( ↑ ) or downregulated ( ↓ ) in both ovarian and peritoneal endometriosis were identified by TARGETSCAN and PICTAR algorithms. MicroRNAs whose regulation is in accordance with the resulting expression of their predicted target genes are reported in bold.
Target genesmicroRNAs upregulatedmicroRNAs downregulated
CA3 (carbonic anhydrase III) ↑ hsa-miR-29b; hsa-miR-29c
CAV1 (caveolin 1) ↑ hsa-miR-199a; hsa-miR-30e-3phsa-miR-20a; hsa-miR-106b
CAV2 (caveolin 2) ↑ hsa-miR-29b; hsa-miR-29c
DMD (dystrophin) ↑ hsa-miR-101; hsa-miR-30e-5phsa-miR-200b; hsa-miR-200c
EPHA3 (EPH receptor A3) ↑ hsa-miR-29b; hsa-miR-29chsa-miR-182
FZD7 ↑ (frizzled homolog 7)hsa-miR-145; hsa-miR-1hsa-miR-20a; hsa-miR-106b
GALNT3 (UDP-N-acetyl-alpha-D-galactosamine) ↓ hsa-miR-30e-5p
KCNMA1 (potassium large conductance calcium-activated channel, subfamily M, alpha mamber 1) ↑ hsa-miR-186hsa-miR-93; hsa-miR-17-5p; hsa-miR-20a; hsa-miR-106b
LMO3 (LIM domain only 3) ↑ hsa-miR-20a; hsa-miR-93; hsa-miR-17-5p; hsa-miR-183; hsa-miR-106b
NFASC (neurofascin) ↑ hsa-miR-150hsa-miR-200b; hsa-miR-200c; hsa-miR-182
PDE4DIP (phosphodiesterase 4D interacting protein) ↑ hsa-miR-183
PLS1 (plastin 1) ↓ hsa-miR-30e-5phsa-miR-17-5p; hsa-miR-20a; hsa-miR-106b
PTPN3 (protein tyrosine phosphatase, non-receptor type 3) ↓ hsa-miR-17-5p; hsa-miR-20a; hsa-miR-106b
RGS2 (regulator of G-protein signalling 2) ↑ hsa-miR-30e-5phsa-miR-182
RGS5 (regulator of G-protein signalling 5) ↑ hsa-miR-186
RPS6KA5 (ribosomal protein S6 kinase, 90 kDa, polypeptide 5) ↓ hsa-miR-148ahsa-miR-93; hsa-miR-17-5p; hsa-miR-20a; hsa-miR-106b
SCAP2 (src family associated phosphoprotein 2) ↑ hsa-miR-182
SLCO3A1 (solute carrier organic anion transporter family, member 3A1) ↑ hsa-miR-34ahsa-miR-182
SNAP25 (synaptosomal-associated protein) ↑ hsa-miR-130a; hsa-miR-1hsa-miR-130b; hsa-miR-200b; hsa-miR-200c
TNFSF12 (tumor necrosis factor superfamily, member 12) ↑ hsa-miR-28