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Journal of Biomedicine and Biotechnology
Volume 2011 (2011), Article ID 195483, 10 pages
http://dx.doi.org/10.1155/2011/195483
Review Article

The Representative Porcine Model for Human Cardiovascular Disease

1Division of Cardiovascular Medicine, Nagoya Heart Center, 461-0045 Aichi, Japan
2Division of Cardiovascular Medicine, School of Medicine, Stanford University, 300 Pasteur Drive, Falk CVRB007, Stanford, CA94305, USA

Received 17 September 2010; Accepted 13 December 2010

Academic Editor: Andrea Vecchione

Copyright © 2011 Yoriyasu Suzuki et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

To improve human health, scientific discoveries must be translated into practical applications. Inherent in the development of these technologies is the role of preclinical testing using animal models. Although significant insight into the molecular and cellular basis has come from small animal models, significant differences exist with regard to cardiovascular characteristics between these models and humans. Therefore, large animal models are essential to develop the discoveries from murine models into clinical therapies and interventions. This paper will provide an overview of the more frequently used large animal models, especially porcine models for preclinical studies.