About this Journal Submit a Manuscript Table of Contents
Journal of Biomedicine and Biotechnology
Volume 2011 (2011), Article ID 271694, 19 pages
http://dx.doi.org/10.1155/2011/271694
Review Article

Murine Models of Systemic Lupus Erythematosus

Department of Pathology, Immunology, and Laboratory Medicine, University of Florida, Gainesville, FL 32610, USA

Received 16 September 2010; Revised 9 December 2010; Accepted 19 December 2010

Academic Editor: Andrea Vecchione

Copyright © 2011 Daniel Perry et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Citations to this Article [53 citations]

The following is the list of published articles that have cited the current article.

  • Nicolas Charles, and Juan Rivera, “Basophils and Autoreactive IgE in the Pathogenesis of Systemic Lupus Erythematosus,” Current Allergy and Asthma Reports, vol. 11, no. 5, pp. 378–387, 2011. View at Publisher · View at Google Scholar
  • Mayami Sengupta, and Laurence Morel, “Lupus at the molecular level,” Protein & Cell, vol. 2, no. 12, pp. 941–943, 2011. View at Publisher · View at Google Scholar
  • Mayami Sengupta, and Laurence Morel, “The role of Pbx1 in T cells,” Protein and Cell, vol. 2, no. 12, pp. 946–949, 2011. View at Publisher · View at Google Scholar
  • Yasunori Iwata, Kengo Furuichi, Shuichi Kaneko, and Takashi Wada, “The Role of Cytokine in the Lupus Nephritis,” Journal of Biomedicine and Biotechnology, vol. 2011, pp. 1–7, 2011. View at Publisher · View at Google Scholar
  • Daniel J. Perry, Yiming Yin, Tiffany Telarico, Henry V. Baker, Igor Dozmorov, Andras Perl, and Laurence Morel, “Murine Lupus Susceptibility Locus Sle1c2 Mediates CD4(+) T Cell Activation and Maps to Estrogen-Related Receptor gamma,” Journal Of Immunology, vol. 189, no. 2, pp. 793–803, 2012. View at Publisher · View at Google Scholar
  • Betty Diamond, and Bruce T. Volpe, “A model for lupus brain disease,” Immunological Reviews, vol. 248, no. 1, pp. 56–67, 2012. View at Publisher · View at Google Scholar
  • Kazuko Fujita, Yoshikiyo Akasaka, Taku Kuwabara, Bing Wang, Kaoru Tanaka, Itaru Kamata, Tomoko Yokoo, Toshio Kinoshita, Ami Iuchi, Yuri Akishima-Fukasawa, Yukio Ishikawa, Motonari Kondo, and Toshiharu Ishii, “Pathogenesis of lupus-like nephritis through autoimmune antibody produced by CD180-negative B lymphocytes in NZBWF1 mouse,” Immunology Letters, vol. 144, no. 1-2, pp. 1–6, 2012. View at Publisher · View at Google Scholar
  • Tai-Ping Lee, and Bor-Luen Chiang, “Sex differences in spontaneous versus induced animal models of autoimmunity,” Autoimmunity Reviews, vol. 11, no. 6-7, pp. A422–A429, 2012. View at Publisher · View at Google Scholar
  • Cassandra M. Berry, Paul J. Hertzog, and Niamh E. Mangan, “Interferons as biomarkers and effectors: lessons learned from animal models,” Biomarkers In Medicine, vol. 6, no. 2, pp. 159–176, 2012. View at Publisher · View at Google Scholar
  • Eiji Suzuki, Eva Karam, Sarah Williams, Dennis K. Watson, Gary Gilkeson, and Xian K. Zhang, “Fli-1 transcription factor affects glomerulonephritis development by regulating expression of monocyte chemoattractant protein-1 in endothelial cells in the kidney,” Clinical Immunology, vol. 145, no. 3, pp. 201–208, 2012. View at Publisher · View at Google Scholar
  • Sebastian Stielke, Gerburg Keilhoff, Elmar Kirches, Peter R. Mertens, Klaus-Hinrich Neumann, George C. Tsokos, and Christian Mawrin, “Adhesion molecule expression precedes brain damages of lupus-prone mice and correlates with kidney pathology,” Journal of Neuroimmunology, vol. 252, no. 1-2, pp. 24–32, 2012. View at Publisher · View at Google Scholar
  • A. M. Campbell, M. Kashgarian, and M. J. Shlomchik, “NADPH Oxidase Inhibits the Pathogenesis of Systemic Lupus Erythematosus,” Science Translational Medicine, vol. 4, no. 157, pp. 157ra141–157ra141, 2012. View at Publisher · View at Google Scholar
  • Yang Pan, Tingting Jia, Yuan Zhang, Kuo Zhang, Rui Zhang, Jinming Li, and Lunan Wang, “MS2 VLP-based delivery of microRNA-146a inhibits autoantibody production in lupus-prone mice,” International Journal Of Nanomedicine, vol. 7, pp. 5957–5967, 2012. View at Publisher · View at Google Scholar
  • Manfred Relle, and Andreas Schwarting, “Role of MHC-Linked Susceptibility Genes in the Pathogenesis of Human and Murine Lupus,” Clinical and Developmental Immunology, vol. 2012, pp. 1–15, 2012. View at Publisher · View at Google Scholar
  • Paola Mina-Osorio, Jacob LaStant, Natalie Keirstead, Toni Whittard, Julia Ayala, Stella Stefanova, Rosario Garrido, Nena Dimaano, Holly Hilton, Mario Giron, Kai-Yeung Lau, Julie Hang, Jennifer Postelnek, Yong Kim, Soo Min, Alka Patel, John Woods, Meera Ramanujam, Julie DeMartino, Satwant Narula, and Daigen Xu, “Suppression of Glomerulonephritis in Lupus-Prone NZB × NZW Mice by RN486, a Selective Inhibitor of Bruton's Tyrosine Kinase,” Arthritis & Rheumatism, vol. 65, no. 9, pp. 2380–2391, 2013. View at Publisher · View at Google Scholar
  • Sibylle Sabrautzki, Eva Janas, Bettina Lorenz-Depiereux, Julia Calzada-Wack, Juan A. Aguilar-Pimentel, Birgit Rathkolb, Thure Adler, Christian Cohrs, Wolfgang Hans, Susanne Diener, Helmut Fuchs, Valerie Gailus-Durner, Dirk H. Busch, Heinz Höfler, Markus Ollert, Tim Matthias Strom, Eckhard Wolf, Frauke Neff, and Martin Hrabě de Angelis, “An ENU Mutagenesis-Derived Mouse Model with a Dominant Jak1 Mutation Resembling Phenotypes of Systemic Autoimmune Disease,” The American Journal of Pathology, 2013. View at Publisher · View at Google Scholar
  • Ganesh V. Halade, Paul J. Williams, Jyothi M. Veigas, Jeffrey L. Barnes, and Gabriel Fernandes, “Concentrated fish oil (Lovaza (R)) extends lifespan and attenuates kidney disease in lupus-prone short-lived (NZBxNZW)F1 mice,” Experimental Biology and Medicine, vol. 238, no. 6, pp. 610–622, 2013. View at Publisher · View at Google Scholar
  • Jun Hao, Yu-jun Zhang, Xin Lv, Ning Xu, Qin-juan Liu, Song Zhao, Xiao-juan Feng, Ling-ling Xing, Peng-peng Kang, Gui-ying Li, and Shu-xia Liu, “IFN-gamma induces lipogenesis in mouse mesangial cells via the JAK2/STAT1 pathway,” American Journal of Physiology-Cell Physiology, vol. 304, no. 8, pp. C760–C767, 2013. View at Publisher · View at Google Scholar
  • Y. Zhao, G. Wen, Z. Qiao, H. Xu, Q. Sun, H. Huang, S. Shan, Z. Mu, and J. Zhang, “Effects of tetra-arsenic tetra-sulfide on BXSB lupus-prone mice: a pilot study,” Lupus, vol. 22, no. 5, pp. 469–476, 2013. View at Publisher · View at Google Scholar
  • Pinar Avci, Magesh Sadasivam, Asheesh Gupta, Wanessa CMA De Melo, Ying-Ying Huang, Rui Yin, Rakkiyappan Chandran, Raj Kumar, Ayodeji Otufowora, Theodore Nyame, and Michael R Hamblin, “Animal models of skin disease for drug discovery,” Expert Opinion on Drug Discovery, vol. 8, no. 3, pp. 331–355, 2013. View at Publisher · View at Google Scholar
  • Mari Sasaki, Akihiro Tojo, Yoshifumi Okochi, Nana Miyawaki, Daisuke Kamimura, Akihito Yamaguchi, Masaaki Murakami, and Yasushi Okamura, “ Autoimmune disorder phenotypes in Hvcn1 -deficient mice ,” Biochemical Journal, vol. 450, no. 2, pp. 295–301, 2013. View at Publisher · View at Google Scholar
  • Shi-jun He, Ze-min Lin, Yan-wei Wu, Bing-xin Bai, Xiao-qian Yang, Pei-lan He, Feng-hua Zhu, Wei Tang, and Jian-ping Zuo, “Therapeutic effects of DZ2002, a reversible SAHH inhibitor, on lupus-prone NZB×NZW F1 mice via interference with TLR-mediated APC response,” Acta Pharmacologica Sinica, vol. 35, no. 2, pp. 219–229, 2013. View at Publisher · View at Google Scholar
  • David G. Winkler, Kerrie L. Faia, Jonathan P. DiNitto, Janid A. Ali, Kerry F. White, Erin E. Brophy, Melissa M. Pink, Jennifer L. Proctor, Jennifer Lussier, Christian M. Martin, Jennifer G. Hoyt, Bonnie Tillotson, Erin L. Murphy, Alice R. Lim, Brian D. Thomas, John R. MacDougall, Pingda Ren, Yi Liu, Lian-Sheng Li, Katti A. Jessen, Christian C. Fritz, Joi L. Dunbar, James R. Porter, Christian Rommel, Vito J. Palombella, Paul S. Changelian, and Jeffery L. Kutok, “PI3K-delta and PI3K-gamma Inhibition by IPI-145 Abrogates Immune Responses and Suppresses Activity in Autoimmune and Inflammatory Disease Models,” Chemistry & Biology, vol. 20, no. 11, pp. 1364–1374, 2013. View at Publisher · View at Google Scholar
  • V. Sisirak, D. Ganguly, K. L. Lewis, C. Couillault, L. Tanaka, S. Bolland, V. D'Agati, K. B. Elkon, and B. Reizis, “Genetic evidence for the role of plasmacytoid dendritic cells in systemic lupus erythematosus,” Journal of Experimental Medicine, 2014. View at Publisher · View at Google Scholar
  • Mara L. Lennard Richard, Tamara K. Nowling, Danielle Brandon, Dennis K. Watson, and Xian K. Zhang, “Fli-1 controls transcription from the MCP-1 gene promoter, which may provide a novel mechanism for chemokine and cytokine activation,” Molecular Immunology, 2014. View at Publisher · View at Google Scholar
  • Tony N. Marion, and Arnold E. Postlethwaite, “Chance, genetics, and the heterogeneity of disease and pathogenesis in systemic lupus erythematosus,” Seminars in Immunopathology, 2014. View at Publisher · View at Google Scholar
  • Hélène Jeltsch-David, and Sylviane Muller, “Neuropsychiatric systemic lupus erythematosus and cognitive dysfunction: The MRL-lpr mouse strain as a model,” Autoimmunity Reviews, 2014. View at Publisher · View at Google Scholar
  • Isharat Yusuf, Jessica Stern, Tom M. McCaughtry, Sandra Gallagher, Hong Sun, Changshou Gao, Thomas Tedder, Gianluca Carlesso, Laura Carter, Ronald Herbst, and Yue Wang, “Germinal Center B Cell Depletion Diminishes CD4(+) Follicular T Helper Cells in Autoimmune Mice,” Plos One, vol. 9, no. 8, 2014. View at Publisher · View at Google Scholar
  • D. A. Decker, C. Grant, L. Oh, P. M. Becker, D. Young, and S. Jordan, “Immunomodulatory effects of HP Acthar Gel on B cell development in the NZB/W F1 mouse model of systemic lupus erythematosus,” Lupus, vol. 23, no. 8, pp. 802–812, 2014. View at Publisher · View at Google Scholar
  • Manuela Frese-Schaper, Andreas Keil, Selina K. Steiner, Mathias Gugger, Meike Körner, Gregor J. Kocher, Lena Schiffer, Hans-Joachim Anders, Uyen Huynh-Do, Ralph A. Schmid, and Steffen Frese, “Low-Dose Irinotecan Improves Advanced Lupus Nephritis in Mice Potentially by Changing DNA Relaxation and Anti-Double-Stranded DNA Binding,” Arthritis & Rheumatology, vol. 66, no. 8, pp. 2259–2269, 2014. View at Publisher · View at Google Scholar
  • Ramalingam Bethunaickan, Celine C. Berthier, Weijia Zhang, Ridvan Eksi, Hong-Dong Li, Yuanfang Guan, Matthias Kretzler, and Anne Davidson, “Identification of Stage-Specific Genes Associated With Lupus Nephritis and Response to Remission Induction in (NZB × NZW)F1 and NZM2410 Mice,” Arthritis & Rheumatology, vol. 66, no. 8, pp. 2246–2258, 2014. View at Publisher · View at Google Scholar
  • D. A. C. Botte, I. L. Noronha, D. M. A. C. Malheiros, T. V. Peixoto, and S. B. V. de Mello, “Alpha-melanocyte stimulating hormone ameliorates disease activity in an induced murine lupus-like model,” Clinical & Experimental Immunology, vol. 177, no. 2, pp. 381–390, 2014. View at Publisher · View at Google Scholar
  • Shih-Shih Chen, and Nicholas Chiorazzi, “Murine genetically-engineered and human xenograft models of chronic lymphocytic leukemia,” Seminars in Hematology, 2014. View at Publisher · View at Google Scholar
  • P. Fagone, K. Mangano, S. Mammana, C. Quattrocchi, G. Magro, M. Coco, S. Imene, R. Di Marco, and F. Nicoletti, “Acceleration of SLE-like syndrome development in NZBxNZW F1 mice by beta-glucan,” Lupus, vol. 23, no. 4, pp. 407–411, 2014. View at Publisher · View at Google Scholar
  • Erin A Kimbrel, Nicholas A Kouris, Gregory Yavanian, Jianlin Chu, Yu Qin, Ann Chan, Ram P Singh, Deborah McCurdy, Lynn Gordon, Ralph D Levinson, and Robert Lanza, “Mesenchymal stem cell population derived from human pluripotent stem cells displays potent immunomodulatory and therapeutic properties,” Stem Cells and Development, pp. 140320053516001, 2014. View at Publisher · View at Google Scholar
  • Issaka Yougbaré, Thérèse Keravis, Abdurazzag Abusnina, Marion Decossas, Nicolas Schall, Sylviane Muller, and Claire Lugnier, “Cyclic GMP catabolism up-regulation in MRL/lpr lupus-prone mice is associated with organ remodeling,” Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease, 2014. View at Publisher · View at Google Scholar
  • Nicole L. Regna, Cristen B. Chafin, Sarah E. Hammond, Abdul G. Puthiyaveetil, David L. Caudell, and Christopher M. Reilly, “Class I and II histone deacetylase inhibition by ITF2357 reduces SLE pathogenesis in vivo,” Clinical Immunology, vol. 151, no. 1, pp. 29–42, 2014. View at Publisher · View at Google Scholar
  • Alexandre Bignon, Francoise Gaudin, Patrice Hemon, Hugo Tharinger, Katia Mayol, Thierry Walzer, Pius Loetscher, Michel Peuchmaur, Dominique Berrebi, and Karl Balabanian, “CCR1 Inhibition Ameliorates the Progression of Lupus Nephritis in NZB/W Mice,” Journal of Immunology, vol. 192, no. 3, pp. 886–896, 2014. View at Publisher · View at Google Scholar
  • Kim Ohl, and Klaus Tenbrock, “Regulatory T cells in systemic lupus erythematosus,” European Journal of Immunology, 2014. View at Publisher · View at Google Scholar
  • Yuan Xu, Haoyang Zhuang, Shuhong Han, Chao Liu, Hai Wang, Clayton E. Mathews, John Massini, Lijun Yang, and Westley H. Reeves, “Mechanisms of Tumor Necrosis Factor α Antagonist-Induced Lupus in a Murine Model,” Arthritis & Rheumatology, vol. 67, no. 1, pp. 225–237, 2014. View at Publisher · View at Google Scholar
  • WeiYu Lin, Dhaya Seshasayee, Wyne P. Lee, Patrick Caplazi, Sami McVay, Eric Suto, Allen Nguyen, Zhonghua Lin, Yonglian Sun, Laura DeForge, Mercedesz Balazs, Flavius Martin, and Ali A. Zarrin, “Dual B Cell Immunotherapy Is Superior to Individual Anti-CD20 Depletion or BAFF Blockade in Murine Models of Spontaneous or Accelerated Lupus,” Arthritis & Rheumatology, vol. 67, no. 1, pp. 215–224, 2014. View at Publisher · View at Google Scholar
  • Husen Zhang, Xiaofeng Liao, Joshua B. Sparks, and Xin M. Luo, “Dynamics of Gut Microbiota in Autoimmune Lupus,” Applied and Environmental Microbiology, vol. 80, no. 24, pp. 7551–7560, 2014. View at Publisher · View at Google Scholar
  • Anupama Tiwari, and Upendra Kumar Soni, “Trigger of autoimmune diseases (SLE): Identification of LINE transposition based novel therapeutic molecular targets,” Medical Hypotheses, vol. 83, no. 6, pp. 825–831, 2014. View at Publisher · View at Google Scholar
  • Samantha A. Chalmers, Violeta Chitu, Leal C. Herlitz, Ranjit Sahu, E. Richard Stanley, and Chaim Putterman, “Macrophage depletion ameliorates nephritis induced by pathogenic antibodies,” Journal of Autoimmunity, 2014. View at Publisher · View at Google Scholar
  • Gaurav Mehta, Viviana P. Ferreira, Christine Skerka, Peter F. Zipfel, and Nirmal K. Banda, “New insights into disease-specific absence of complement factor H related protein C in mouse models of spontaneous autoimmune diseases,” Molecular Immunology, vol. 62, no. 1, pp. 235–248, 2014. View at Publisher · View at Google Scholar
  • Fahimeh Lavi Arab, Maryam Rastin, Fatemeh Faraji, Shahrzad Zamani Taghizadeh Rabe, Nafise Tabasi, Mahdieh Khazaee, Dariush Haghmorad, and Mahmoud Mahmoudi, “Assessment of 1,25-dihydroxyvitamin D3 effects on Treg cells in a mouse model of systemic lupus erythematosus,” Immunopharmacology and Immunotoxicology, pp. 1–7, 2014. View at Publisher · View at Google Scholar
  • Andrew T. Bender, Yin Wu, Qiongfong Cao, Yueyun Ding, Judith Oestreicher, Melinda Genest, Sandeep Akare, Sally T. Ishizaka, and Matthew F. Mackey, “Assessment of the translational value of mouse lupus models using clinically relevant biomarkers,” Translational Research, 2014. View at Publisher · View at Google Scholar
  • K. Ohl, A. Wiener, A. Schippers, N. Wagner, and K. Tenbrock, “ Interleukin-2 treatment reverses effects of cAMP-responsive element modulator α -over-expressing T cells in autoimmune-prone mice ,” Clinical & Experimental Immunology, 2015. View at Publisher · View at Google Scholar
  • Jessica L. Grieves, Jason M. Fye, Scott Harvey, Jason M. Grayson, Thomas Hollis, and Fred W. Perrino, “Exonuclease TREX1 degrades double-stranded DNA to prevent spontaneous lupus-like inflammatory disease,” Proceedings of the National Academy of Sciences, vol. 112, no. 16, pp. 5117–5122, 2015. View at Publisher · View at Google Scholar
  • Annemarie EM van Nieuwenhuijze, Bénédicte Cauwe, Denise Klatt, Stéphanie Humblet-Baron, and Adrian Liston, “Lpr-induced systemic autoimmunity is unaffected by mast cell deficiency,” Immunology and Cell Biology, 2015. View at Publisher · View at Google Scholar
  • David T. Rodgers, Mairi A. McGrath, Miguel A. Pineda, Lamyaa Al-Riyami, Justyna Rzepecka, Felicity Lumb, William Harnett, and Margaret M. Harnett, “ The Parasitic Worm Product ES-62 Targets Myeloid Differentiation Factor 88-Dependent Effector Mechanisms to Suppress Antinuclear Antibody Production and Proteinuria in MRL/ lpr Mice ,” Arthritis & Rheumatology, vol. 67, no. 4, pp. 1023–1035, 2015. View at Publisher · View at Google Scholar
  • Xiaofeng Liao, Jingjing Ren, Cheng-Hsin Wei, A. Catharine Ross, Thomas E. Cecere, Bernard S. Jortner, S. Ansar Ahmed, and Xin M. Luo, “Paradoxical Effects of All-Trans-Retinoic Acid on Lupus-Like Disease in the MRL/lpr Mouse Model,” Plos One, vol. 10, no. 3, 2015. View at Publisher · View at Google Scholar
  • Abhishek Trigunaite, Joana Dimo, and Trine N. Jørgensen, “Suppressive effects of androgens on the immune system,” Cellular Immunology, 2015. View at Publisher · View at Google Scholar