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Journal of Biomedicine and Biotechnology
Volume 2011 (2011), Article ID 464701, 9 pages
Middle Cerebral Artery Occlusion Model in Rodents: Methods and Potential Pitfalls
1Department of Neuroscience, University of Connecticut Health Center, Farmington, CT 06030, USA
2Department of Neurology, University of Connecticut Health Center and The Stroke Center at Hartford Hospital, 263 Farmington Avenue, Farmington, CT 06030, USA
Received 15 September 2010; Revised 23 December 2010; Accepted 23 December 2010
Academic Editor: Andrea Vecchione
Copyright © 2011 Fudong Liu and Louise D. McCullough. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Citations to this Article [35 citations]
The following is the list of published articles that have cited the current article.
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- Md Nasrul Hoda, Weiguo Li, Ajmal Ahmad, Safia Ogbi, Marina A. Zemskova, Maribeth H. Johnson, Adviye Ergul, William D. Hill, David C. Hess, and Irina Y. Sazonova, “Sex-independent neuroprotection with minocycline after experimental thromboembolic stroke,” Experimental and Translational Stroke Medicine, vol. 3, no. 1, 2011.
- Bharti Manwani, Fudong Liu, Yan Xu, Rebecca Persky, Jun Li, and Louise D. McCullough, “Functional recovery in aging mice after experimental stroke,” Brain Behavior and Immunity, vol. 25, no. 8, pp. 1689–1700, 2011.
- Ming-He Cheng, Li-Li Lin, Ji-Yong Liu, and Ai-Jun Liu, “The Outcomes of Stroke Induced by Middle Cerebral Artery Occlusion in Different Strains of Mice,” CNS Neuroscience & Therapeutics, vol. 18, no. 9, pp. 794–795, 2012.
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- Abraham Martin, Emilie Mace, Raphael Boisgard, Gabriel Montaldo, Benoit Theze, Mickael Tanter, and Bertrand Tavitian, “Imaging of perfusion, angiogenesis, and tissue elasticity after stroke,” Journal of Cerebral Blood Flow and Metabolism, vol. 32, no. 8, pp. 1496–1507, 2012.
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- Mian Zhou, Christie M. Wang, Weng-Lang Yang, and Ping Wang, “Microglial CD14 activated by iNOS contributes to neuroinflammation in cerebral ischemia,” Brain Research, vol. 1506, pp. 105–114, 2013.
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- Seunghoon Lee, Yunkyung Hong, Sookyoung Park, Sang-Rae Lee, Kyu-Tae Chang, and Yonggeun Hong, “Comparison of Surgical Methods of Transient Middle Cerebral Artery Occlusion between Rats and Mice,” Journal Of Veterinary Medical Science, vol. 76, no. 12, pp. 1555–1561, 2014.
- Slavianka Moyanova, and Rick Dijkhuizen, “Present status and future challenges of electroencephalography- and magnetic resonance imaging-based monitoring in preclinical models of focal cerebral ischemia,” Brain Research Bulletin, 2014.
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