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Journal of Biomedicine and Biotechnology
Volume 2011 (2011), Article ID 518323, 9 pages
http://dx.doi.org/10.1155/2011/518323
Review Article

Laboratory Animal Models for Brucellosis Research

1Departamento de Clínica e Cirurgia Veterinária, Escola de Veterinária (EV), Universidade Federal de Minas Gerais (UFMG), 31270-901 Belo Horizonte, MG, Brazil
2Departamento de Patologia Geral, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais, 31270-901 Belo Horizonte, MG, Brazil
3Department of Medical Microbiology and Immunology, University of California, Davis, Davis, CA 95616, USA

Received 14 September 2010; Revised 25 November 2010; Accepted 11 January 2011

Academic Editor: Oreste Gualillo

Copyright © 2011 Teane M. A. Silva et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Brucellosis is a chronic infectious disease caused by Brucella spp., a Gram-negative facultative intracellular pathogen that affects humans and animals, leading to significant impact on public health and animal industry. Human brucellosis is considered the most prevalent bacterial zoonosis in the world and is characterized by fever, weight loss, depression, hepato/splenomegaly, osteoarticular, and genital infections. Relevant aspects of Brucella pathogenesis have been intensively investigated in culture cells and animal models. The mouse is the animal model more commonly used to study chronic infection caused by Brucella. This model is most frequently used to investigate specific pathogenic factors of Brucella spp., to characterize the host immune response, and to evaluate therapeutics and vaccines. Other animal species have been used as models for brucellosis including rats, guinea pigs, and monkeys. This paper discusses the murine and other laboratory animal models for human and animal brucellosis.