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Journal of Biomedicine and Biotechnology
Volume 2011 (2011), Article ID 609813, 6 pages
Review Article

Perinatal Hypoxic-Ischemic Encephalopathy

1Department of Pediatrics, Chi Mei Medical Center, Tainan, Taiwan
2Graduate Institute of Medicine, Kaohsiung Medical University, No. 100, Zihyou 1st Road, Sanmin District Kaohsiung City 807, Taiwan
3Center of Excellence for Environmental Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan
4Department of Pediatrics, Kaohsiung Medical University Hospital, Kaohsiung, Taiwan
5Department of Marine Biotechnology and Resources, National Sun Yat-sen University, Kaohsiung, Taiwan

Received 15 September 2010; Accepted 8 November 2010

Academic Editor: Oreste Gualillo

Copyright © 2011 Ming-Chi Lai and San-Nan Yang. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Perinatal hypoxic-ischemic encephalopathy (HIE) is an important cause of brain injury in the newborn and can result in long-term devastating consequences. Perinatal hypoxia is a vital cause of long-term neurologic complications varying from mild behavioural deficits to severe seizure, mental retardation, and/or cerebral palsy in the newborn. In the mammalian developing brain, ongoing research into pathophysiological mechanism of neuronal injury and therapeutic strategy after perinatal hypoxia is still limited. With the advent of promising therapy of hypothermia in HIE, this paper reviews the pathophysiology of HIE and the future potential neuroprotective strategies for clinical potential for hypoxia sufferers.