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Journal of Biomedicine and Biotechnology
Volume 2011 (2011), Article ID 617974, 12 pages
http://dx.doi.org/10.1155/2011/617974
Research Article

Presenilin-2 Mutation Causes Early Amyloid Accumulation and Memory Impairment in a Transgenic Mouse Model of Alzheimer's Disease

1Molecular Gerontology, Tokyo Metropolitan Institute of Gerontology, 35-2 Sakae-Cho, Itabashi-Ku, Tokyo 173-0015, Japan
2JAC Co, Ltd, 1-2-7 Higashiyama, Meguro-Ku, Tokyo 153-0043, Japan
3Immuno-Biological Laboratories Co, Ltd., 1091-1 Naka, Aza-Higashida, Fujioka-shi, Gunma 370-0831, Japan

Received 15 September 2010; Revised 17 November 2010; Accepted 4 December 2010

Academic Editor: Monica Fedele

Copyright © 2011 Toshihiko Toda et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Supplementary Material

Supplementary experimental procedures:

Respirometry monitored using metabolic cages, Locomotive activity monitored using implanted transmitting devices, Y maze, Elevated plus maze, Open field test, and Statistical Analyses.

  1. Supplementary Material