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Journal of Biomedicine and Biotechnology
Volume 2011 (2011), Article ID 903097, 8 pages
http://dx.doi.org/10.1155/2011/903097
Review Article

Methotrexate Toxicity in Growing Long Bones of Young Rats: A Model for Studying Cancer Chemotherapy-Induced Bone Growth Defects in Children

1Sansom Institute for Health Research, and School of Pharmacy and Medical Sciences, University of South Australia, City East Campus, GPO Box 2471, Adelaide, SA 5001, Australia
2Discipline of Paediatrics, University of Adelaide, Adelaide, SA 5005, Australia
3Discipline of Physiology, University of Adelaide, Adelaide, SA 5005, Australia

Received 10 September 2010; Accepted 21 January 2011

Academic Editor: Andrea Vecchione

Copyright © 2011 Chiaming Fan et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Citations to this Article [6 citations]

The following is the list of published articles that have cited the current article.

  • Tristan J. King, Kristen R. Georgiou, Johanna C. Cool, Michaela A. Scherer, Estabelle S.M. Ang, Bruce K. Foster, Jiake Xu, and Cory J. Xian, “Methotrexate Chemotherapy Promotes Osteoclast Formation in the Long Bone of Rats via Increased Pro-Inflammatory Cytokines and Enhanced NF-κB Activation,” The American Journal of Pathology, vol. 181, no. 1, pp. 121–129, 2012. View at Publisher · View at Google Scholar
  • Chia-Ming Fan, Bruce K. Foster, Susanta K. Hui, and Cory J. Xian, “Prevention of Bone Growth Defects, Increased Bone Resorption and Marrow Adiposity with Folinic Acid in Rats Receiving Long-Term Methotrexate,” PLoS ONE, vol. 7, no. 10, 2012. View at Publisher · View at Google Scholar
  • Stella D'Oronzo, Antonella Tamma, Valeria Simone, Vito Longo, and Franco Silvestris, “Bone health in the oncologic patient,” Recenti Progressi in Medicina, vol. 103, no. 10, pp. 373–383, 2012. View at Publisher · View at Google Scholar
  • G. Subramanian, and S.Y.P. Quek, “Comment on Narváez et al.: Lack of response to teriparatide therapy for bisphosphonate-associated osteonecrosis of the jaw,” Osteoporosis International, vol. 24, no. 2, pp. 735–736, 2013. View at Publisher · View at Google Scholar
  • Rethi Raghu Nadhanan, Chia-Ming Fan, Yu-Wen Su, Peter R.C. Howe, and Cory J. Xian, “Fish oil in comparison to folinic acid for protection against adverse effects of methotrexate chemotherapy on bone,” Journal of Orthopaedic Research, vol. 32, no. 4, pp. 587–596, 2013. View at Publisher · View at Google Scholar
  • Chiaming Fan, Maria Garcia, Michaela Scherer, and C Cuong Tran, “Potential roles of metallothioneins I and II in protecting bone growth foll owing acute methotrexate chemotherapy,” Journal of Chemotherapy, vol. 26, no. 1, pp. 37–48, 2014. View at Publisher · View at Google Scholar