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Journal of Biomedicine and Biotechnology
Volume 2011 (2011), Article ID 907575, 12 pages
http://dx.doi.org/10.1155/2011/907575
Review Article

Atherosclerosis and Thrombosis: Insights from Large Animal Models

1Cardiovascular Research Center (CSIC-ICCC), Hospital de la Santa Creu i Sant Pau, IIB-Sant Pau, 08025 Barcelona, Spain
2CIBERobn, Barcelona, Spain
3Autonomous University of Barcelona (UAB), Barcelona, Spain

Received 23 September 2010; Accepted 9 December 2010

Academic Editor: Oreste Gualillo

Copyright © 2011 Gemma Vilahur et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Atherosclerosis and its thrombotic complications are responsible for remarkably high numbers of deaths. The combination of in vitro, ex vivo, and in vivo experimental approaches has largely contributed to a better understanding of the mechanisms underlying the atherothrombotic process. Indeed, different animal models have been implemented in atherosclerosis and thrombosis research in order to provide new insights into the mechanisms that have already been outlined in isolated cells and protein studies. Yet, although no model completely mimics the human pathology, large animal models have demonstrated better suitability for translation to humans. Indeed, direct translation from mice to humans should be taken with caution because of the well-reported species-related differences. This paper provides an overview of the available atherothrombotic-like animal models, with a particular focus on large animal models of thrombosis and atherosclerosis, and examines their applicability for translational research purposes as well as highlights species-related differences with humans.