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Journal of Biomedicine and Biotechnology
Volume 2011 (2011), Article ID 939023, 11 pages
http://dx.doi.org/10.1155/2011/939023
Review Article

The Animal Model of Spinal Cord Injury as an Experimental Pain Model

1Department of Anesthesiology & Intensive Care, Osaka University Graduate School of Medicine, 2-2 Yamadaoka Suita, Osaka 565-0871, Japan
2Department of Breast Regenerative Medicine, Osaka University Graduate School of Medicine, Osaka 565-0871, Japan
3Department of Plastic Surgery, Osaka University Graduate School of Medicine, Osaka 565-0871, Japan
4Department of Pain Medicine, Osaka University Graduate School of Medicine, Osaka 565-0871, Japan

Received 13 September 2010; Accepted 19 December 2010

Academic Editor: Andrea Vecchione

Copyright © 2011 Aya Nakae et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Pain, which remains largely unsolved, is one of the most crucial problems for spinal cord injury patients. Due to sensory problems, as well as motor dysfunctions, spinal cord injury research has proven to be complex and difficult. Furthermore, many types of pain are associated with spinal cord injury, such as neuropathic, visceral, and musculoskeletal pain. Many animal models of spinal cord injury exist to emulate clinical situations, which could help to determine common mechanisms of pathology. However, results can be easily misunderstood and falsely interpreted. Therefore, it is important to fully understand the symptoms of human spinal cord injury, as well as the various spinal cord injury models and the possible pathologies. The present paper summarizes results from animal models of spinal cord injury, as well as the most effective use of these models.