Distinct Effects of Contraction-Induced Injury In Vivo on Four Different Murine Models of Dysferlinopathy
Figure 8
Quantitation of macrophages (CD68+ cells). We counted macrophages in cross sections of uninjured and injured TA labeled with antibodies to CD68 (see Figure 4). All dysferlin mutant strains showed elevated macrophage counts at D3 post-LSI, with A/J having significantly higher levels than the other strains. DMDmdx muscle showed significantly higher macrophage infiltration than A/J. *Significant difference compared to control strain at same time point. #Significant difference within same strain between uninjured and D3. †Significant difference compared to same Dysf mutation at same time point. ‡Significant difference compared to A/J at same time point.
