420364.fig.003a
(a)
420364.fig.003b
(b)
420364.fig.003c
(c)
420364.fig.003d
(d)
Figure 3: Homing of GSCT peptide to GSC-derived tumors in vivo [27]. (a) In vivo biodistribution of GSCT peptide was examined by intravenous injection of Q-dot 800-conjugated GSCT (QGSCT) or control peptide in mice bearing subcutaneous tumors derived from the injection of Id4-driven mouse GSCs. Whole-body biofluorescence images were obtained 24 h after injection of Q-GSCT and Q-control peptides. (b) In vivo biodistribution of Q-Dot 800-conjugated GSCT or control peptide in orthotopic brain tumor models. Whole-body biofluorescence images were obtained 4 days after injection of Q-GSCT and Q-control peptides in mice bearing orthotopic brain tumors derived from the injection of Id4-driven mouse GSCs. (c) Fluorescence images of Q-GSCT peptides in tumors and organs extracted from mice bearing subcutaneous tumors are shown in Figure 3(a). (d) Fluorescence images of Q-GSCT peptides in brains extracted from mice bearing orthotopic tumors are shown in Figure 3(b). With reprint permission from Elsevier.