Table 3: Sum of toxicity patterns matching doxorubicin-induced metabolite changes.

ToxicityDoxorubicin, low doseDoxorubicin, high dose

Blood, anemia2
Bone marrow, suppression22
Hormones, antiandrogen1
Systemic antiproliferative1
Kidney, tubular toxicity1
Liver toxicity1
Liver, enzyme induction2
Thyroid, indirect effects1

Grand total310

See the legend for Table 1.