Research Article
Prediction of Clinically Relevant Safety Signals of Nephrotoxicity through Plasma Metabolite Profiling
Table 3
Sum of toxicity patterns matching doxorubicin-induced metabolite changes.
| Toxicity | Doxorubicin, low dose | Doxorubicin, high dose |
| Blood, anemia | | 2 | Bone marrow, suppression | 2 | 2 | Hormones, antiandrogen | | 1 | Systemic antiproliferative | | 1 | Kidney, tubular toxicity | 1 | | Liver toxicity | | 1 | Liver, enzyme induction | | 2 | Thyroid, indirect effects | | 1 |
| Grand total | 3 | 10 |
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See the legend for Table 1.
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