Table 4: Sum of toxicity patterns matching captopril-induced metabolite changes.

ToxicityCaptopril, low doseCaptopril, high dose

Adrenals, steroid biosynthesis inhibition1
Bone marrow, suppression2
Kidney, glomerular tubular defect13
Kidney, tubular toxicity2
Liver, oxidative stress3
Phthalate toxicity1

Grand total94

See the legend for Table 1.