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BioMed Research International
Volume 2013 (2013), Article ID 267375, 8 pages
http://dx.doi.org/10.1155/2013/267375
Research Article

Identification of Lung-Cancer-Related Genes with the Shortest Path Approach in a Protein-Protein Interaction Network

1The Key Laboratory of Stem Cell Biology, Institute of Health Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 200031, China
2Key Laboratory of Systems Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 200031, China
3Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China
4College of Information Engineering, Shanghai Maritime University, Shanghai 201306, China
5Department of Ophthalmology, Shanghai First People's Hospital, Shanghai Jiaotong University, Shanghai 200080, China
6Department of Biomedical Engineering Tianjin University, Tianjin Key Lab of BME Measurement, Tianjin 300072, China
7CAS-MPG Partner Institute for Computational Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 200031, China
8Department of Genetics and Genomic Sciences, Mount Sinai School of Medicine, New York, NY 10029, USA
9Institute of Systems Biology, Shanghai University, Shanghai 200444, China

Received 12 March 2013; Revised 19 April 2013; Accepted 29 April 2013

Academic Editor: Bing Niu

Copyright © 2013 Bi-Qing Li et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Supplementary Material

Additional file S1: This file contains two sheets. The first one shows 54 NSCLC related genes compiled from KEGG and corresponding Ensembl protein ID. The second one shows 84 SCLC related genes compiled from KEGG and corresponding Ensembl protein ID.

Additional file S2: This file contains four sheets. The first one shows the 1918 overexpressed probes in NSCLC compared with normal tissues identified from gene expression array GSE40275. The second one shows the 2243 downexpressed probes in NSCLC. The third one shows the 819 overexpressed probes in SCLC. The fourth one shows the 820 downexpressed probes in SCLC.

Additional file S3: This file contains five gene sets. The first one is the total 1825 differentially expressed NSCLC genes corresponding to the differentially expressed probes listed in Additional file S2. The second one is the total 1063 SCLC differentially expressed genes corresponding to the differentially expressed probes listed in Additional file S2. The third one is the 25 NSCLC shortest path genes. The fourth one is the 38 SCLC shortest path genes. The fifth one is the 742 cancer genes.

Additional file S4: 1711 shortest paths between 54 NSCLC genes and 3916 shortest paths between 84 SCLC genes.

Additional file S5: This file contains two sheets. The first one shows the 114 NSCLC shortest path genes with p-value. The second one shows the 161 SCLC shortest path genes with p-value.

Additional file S6: This file contains two sheets. The first one shows the GO enrichment result of 25 NSCLC shortest path genes. The second one shows the GO enrichment result of 38 SCLC shortest path genes.

  1. Supplementary Material