Triterpenes and the Antimycobacterial Activity of Duroia macrophylla Huber (Rubiaceae)

Table 2

Minimum inhibitory concentration (MIC) of D. macrophylla extracts against M. tuberculosis strains.

	M. tuberculosis
Extracts	H37Rv		INHr		RMPr
	(𝜇g/mL)		(𝜇g/mL)		(𝜇g/mL)
1st Collection
Leaves DCM	S	6.25	S	25	S	≤ 6.25
Leaves MeOH	R	>200	R	>200	S	200
Branches DCM	S	100	S	100	S	100
Branches MeOH	R	>200	R	>200	R	>200
2nd Collection
Leaves DCM	S	200	S	50	R	>200
Leaves MeOH	S	100	S	12.5	S	100
Branches DCM	S	25	S	50	R	>200
Branches MeOH	S	100	S	100	S	100

DCM: dichloromethane, MeOH: methanol, R: resistant, S: sensible, H37Rv: sensible strain, INHr: isoniazid resistant strain, RMPr: rifampicin resistant strain. Extract with MIC > 200 μg/mL were considered inactive.