The Immunobiology of Prostanoid Receptor Signaling in Connecting Innate and Adaptive Immunity
Figure 2
PGE2 and PGD2 receptor signaling during DC-T cell interaction in normal and pathological conditions. (a) During antigen presentation, PGE2 can be produced by DCs and acts on DC function and T cell differentiation through EP2/EP4 receptor signaling. Tumor cells are also an important source of PGE2, which acts as a potent suppressor of the APC function of DCs. (b) PGD2 produced by DCs and/or mast cells markedly affects T cell and DC functions via DP1 receptor signaling. PGD2 can also stimulate Th2 cell through CRTH2 signal.
