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BioMed Research International
Volume 2013 (2013), Article ID 921348, 6 pages
http://dx.doi.org/10.1155/2013/921348
Research Article

Possible Role of Hyperinsulinemia and Insulin Resistance in Lower Vitamin D Levels in Overweight and Obese Patients

1Clinical Nutrition Unit, Department of Biomedical Sciences and Human Oncology, Section of Clinical Oncology, School of Medicine, University of Bari, Policlinico, Piazza Giulio Cesare 11, 70124 Bari, Italy
2Department of Biomedical Sciences and Human Oncology, School of Medicine, University of Bari, Policlinico, Piazza Giulio Cesare, 70124 Bari, Italy
3Outpatient Clinic for Metabolic Diseases and Endocrinology, Conversano Hospital, ASL Bari, 70014 Conversano, Italy
4Section of Endocrinology and Metabolic Diseases, Department of Emergency and Organ Transplantation, School of Medicine, University of Bari, Policlinico, Piazza Giulio Cesare, 70124 Bari, Italy

Received 5 August 2012; Revised 6 December 2012; Accepted 8 December 2012

Academic Editor: Joseph Fomusi Ndisang

Copyright © 2013 Giovanni De Pergola et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. M. F. Holick, “Medical progress: vitamin D deficiency,” The New England Journal of Medicine, vol. 357, no. 3, pp. 266–281, 2007. View at Publisher · View at Google Scholar · View at Scopus
  2. B. Dawson-Hughes, “Serum 25-hydroxyvitamin D and functional outcomes in the elderly,” American Journal of Clinical Nutrition, vol. 88, no. 2, pp. S537–S540, 2008. View at Scopus
  3. N. M. van Schoor, M. Visser, S. M. F. Pluijm, N. Kuchuk, J. H. Smit, and P. Lips, “Vitamin D deficiency as a risk factor for osteoporotic fractures,” Bone, vol. 42, no. 2, pp. 260–266, 2008. View at Publisher · View at Google Scholar · View at Scopus
  4. S. Nagpal, S. Na, and R. Rathnachalam, “Noncalcemic actions of vitamin D receptor ligands,” Endocrine Reviews, vol. 26, no. 5, pp. 662–687, 2005. View at Publisher · View at Google Scholar · View at Scopus
  5. C. J. Rosen, “Vitamin D insufficiency,” The New England Journal of Medicine, vol. 364, no. 3, pp. 248–254, 2011. View at Publisher · View at Google Scholar · View at Scopus
  6. S. J. Parikh, M. Edelman, G. I. Uwaifo et al., “The relationship between obesity and serum 1,25-dihydroxy vitamin D concentrations in healthy adults,” Journal of Clinical Endocrinology and Metabolism, vol. 89, no. 3, pp. 1196–1199, 2004. View at Publisher · View at Google Scholar · View at Scopus
  7. S. Cheng, J. M. Massaro, C. S. Fox et al., “Adiposity, cardiometabolic risk, and vitamin D status: the framingham heart study,” Diabetes, vol. 59, no. 1, pp. 242–248, 2010. View at Publisher · View at Google Scholar · View at Scopus
  8. A. G. Need, P. D. O'Loughlin, M. Horowitz, and B. E. C. Nordin, “Relationship between fasting serum glucose, age, body mass index and serum 25 hydroxyvitamin D in postmenopausal women,” Clinical Endocrinology, vol. 62, no. 6, pp. 738–741, 2005. View at Publisher · View at Google Scholar · View at Scopus
  9. S. Konradsen, H. Ag, F. Lindberg, S. Hexeberg, and R. Jorde, “Serum 1,25-dihydroxy vitamin D is inversely associated with body mass index,” European Journal of Nutrition, vol. 47, no. 2, pp. 87–91, 2008. View at Publisher · View at Google Scholar · View at Scopus
  10. E. Liu, J. B. Meigs, A. G. Pittas et al., “Predicted 25-hydroxyvitamin D score and incident type 2 diabetes in the Framingham Offspring Study,” American Journal of Clinical Nutrition, vol. 91, no. 6, pp. 1627–1633, 2010. View at Publisher · View at Google Scholar · View at Scopus
  11. R. Scragg, M. Sowers, and C. Bell, “Serum 25-hydroxyvitamin D, diabetes, and ethnicity in the Third National Health and Nutrition Examination Survey,” Diabetes Care, vol. 27, no. 12, pp. 2813–2818, 2004. View at Publisher · View at Google Scholar · View at Scopus
  12. L. Lu, Z. Yu, A. Pan et al., “Plasma 25-hydroxyvitamin D concentration and metabolic syndrome among middle-aged and elderly Chinese individuals,” Diabetes Care, vol. 32, no. 7, pp. 1278–1283, 2009. View at Publisher · View at Google Scholar · View at Scopus
  13. G. Zhao, E. S. Ford, and C. Li, “Associations of serum concentrations of 25-hydroxyvitamin D and parathyroid hormone with surrogate markers of insulin resistance among U.S. adults without physician-diagnosed diabetes: NHANES, 2003–2006,” Diabetes Care, vol. 33, no. 2, pp. 344–347, 2010. View at Publisher · View at Google Scholar · View at Scopus
  14. E. Liu, J. B. Meigs, A. G. Pittas et al., “Plasma 25-hydroxyvitamin D is associated with markers of the insulin resistant phenotype in nondiabetic adults,” Journal of Nutrition, vol. 139, no. 2, pp. 329–334, 2009. View at Publisher · View at Google Scholar · View at Scopus
  15. K. C. Chiu, A. Chu, V. L. W. Go, and M. F. Saad, “Hypovitaminosis D is associated with insulin resistance and β cell dysfunction,” American Journal of Clinical Nutrition, vol. 79, no. 5, pp. 820–825, 2004. View at Scopus
  16. K. L. Jablonski, M. Chonchol, G. L. Pierce, A. E. Walker, and D. R. Seals, “25-Hydroxyvitamin D deficiency is associated with inflammation-linked vascular endothelial dysfunction in middle-aged and older adults,” Hypertension, vol. 57, no. 1, pp. 63–69, 2011. View at Publisher · View at Google Scholar · View at Scopus
  17. C. A. Peterson and M. E. Heffernan, “Serum tumor necrosis factor-alpha concentrations are negatively correlated with serum 25(OH)D concentrations in healthy women,” Journal of Inflammation, vol. 5, article no. 10, 2008. View at Publisher · View at Google Scholar · View at Scopus
  18. D. T. Ngo, A. L. Sverdlov, J. J. McNeil, and J. D. Horowitz, “Does vitamin D modulate asymmetric dimethylarginine and C-reactive protein concentrations?” American Journal of Medicine, vol. 123, no. 4, pp. 335–341, 2010. View at Publisher · View at Google Scholar · View at Scopus
  19. H. Dobnig, S. Pilz, H. Scharnagl et al., “Independent association of low serum 25-hydroxyvitamin D and 1,25-dihydroxyvitamin D levels with all-cause and cardiovascular mortality,” Archives of Internal Medicine, vol. 168, no. 12, pp. 1340–1349, 2008. View at Publisher · View at Google Scholar · View at Scopus
  20. A. Bellia, C. Garcovich, M. D’Adamo, et al., “Serum 25-hydroxyvitamin D levels are inversely associated with systemic inflammation in severe obese subjects,” Internal and Emergency Medicine. In press. View at Publisher · View at Google Scholar
  21. E. Hyppönen, D. Berry, M. Cortina-Borja, and C. Power, “25-Hydroxyvitamin D and pre-clinical alterations in inflammatory and hemostatic markers: a cross sectional analysis in the 1958 British Birth Cohort,” PloS one, vol. 5, no. 5, Article ID e10801, 2010. View at Publisher · View at Google Scholar · View at Scopus
  22. C. A. Peterson and M. E. Heffernan, “Serum tumor necrosis factor-alpha concentrations are negatively correlated with serum 25(OH)D concentrations in healthy women,” Journal of Inflammation, vol. 5, article no. 10, 2008. View at Publisher · View at Google Scholar · View at Scopus
  23. N. Vilarrasa, J. Vendrell, J. Maravall et al., “Is plasma 25(OH) D related to adipokines, inflammatory cytokines and insulin resistance in both a healthy and morbidly obese population?” Endocrine, vol. 38, no. 2, pp. 235–242, 2010. View at Publisher · View at Google Scholar · View at Scopus
  24. A. Zittermann, S. Frisch, H. K. Berthold et al., “Vitamin D supplementation enhances the beneficial effects of weight loss on cardiovascular disease risk markers,” American Journal of Clinical Nutrition, vol. 89, no. 5, pp. 1321–1327, 2009. View at Publisher · View at Google Scholar · View at Scopus
  25. M. Amer and R. Qayyum, “Relation between serum 25-hydroxyvitamin D and C-reactive protein in asymptomatic adults (from the continuous National Health and Nutrition Examination Survey 2001 to 2006),” American Journal of Cardiology, vol. 109, pp. 226–230, 2012. View at Publisher · View at Google Scholar
  26. V. Mohamed-Ali, S. Goodrick, A. Rawesh et al., “Subcutaneous adipose tissue releases interleukin-6, but not tumor necrosis factor-α, in vivo,” Journal of Clinical Endocrinology and Metabolism, vol. 82, no. 12, pp. 4196–4200, 1997. View at Scopus
  27. B. G. Gabrielsson, J. M. Johansson, M. Lönn et al., “High expression of complement components in omental adipose tissue in obese men,” Obesity Research, vol. 11, no. 6, pp. 699–708, 2003. View at Scopus
  28. H. A. Koistinen, H. Vidal, S. L. Karonen et al., “Plasma acylation stimulating protein concentration and subcutaneous adipose tissue C3 mRNA expression in nondiabetic and type 2 diabetic men,” Arteriosclerosis, Thrombosis, and Vascular Biology, vol. 21, no. 6, pp. 1034–1039, 2001. View at Scopus
  29. A. Muscari, G. Massarelli, L. Bastagli et al., “Relationship of serum C3 to fasting insulin, risk factors and previous ischaemic events in middle-aged men,” European Heart Journal, vol. 21, no. 13, pp. 1081–1090, 2000. View at Publisher · View at Google Scholar · View at Scopus
  30. A. Muscari, S. Antonelli, G. Bianchi et al., “Serum C3 is a stronger inflammatory marker of insulin resistance than C-reactive protein, leukocyte count, and erythrocyte sedimentation rate: Comparison study in an elderly population,” Diabetes Care, vol. 30, no. 9, pp. 2362–2368, 2007. View at Publisher · View at Google Scholar · View at Scopus
  31. G. De Pergola, M. M. Ciccone, P. Guida et al., “Relationship between C3 levels and common carotid intima-media thickness in overweight and obese patients,” Obesity Facts, vol. 4, no. 2, pp. 159–163, 2011. View at Publisher · View at Google Scholar · View at Scopus
  32. T. A. Pearson, G. A. Mensah, R. W. Alexander et al., “Markers of inflammation and cardiovascular disease: Application to clinical and public health practice: a statement for healthcare professionals from the centers for disease control and prevention and the American Heart Association,” Circulation, vol. 107, no. 3, pp. 499–511, 2003. View at Publisher · View at Google Scholar · View at Scopus
  33. E. Bonora, G. Targher, M. Alberiche et al., “Homeostasis model assessment closely mirrors the glucose clamp technique in the assessment of insulin sensitivity: studies in subjects with various degrees of glucose tolerance and insulin sensitivity,” Diabetes Care, vol. 23, no. 1, pp. 57–63, 2000. View at Scopus
  34. J. Wortsman, L. Y. Matsuoka, T. C. Chen, Z. Lu, and M. F. Holick, “Decreased bioavailability of vitamin D in obesity,” American Journal of Clinical Nutrition, vol. 72, no. 3, pp. 690–693, 2000. View at Scopus
  35. T. Tzotzas, F. G. Papadopoulou, K. Tziomalos et al., “Rising serum 25-hydroxy-vitamin D levels after weight loss in obese women correlate with improvement in insulin resistance,” Journal of Clinical Endocrinology and Metabolism, vol. 95, no. 9, pp. 4251–4257, 2010. View at Publisher · View at Google Scholar · View at Scopus
  36. D. R. Shahar, D. Schwarzfuchs, D. Fraser et al., “Dairy calcium intake, serum vitamin D, and successful weight loss,” American Journal of Clinical Nutrition, vol. 92, no. 5, pp. 1017–1022, 2010. View at Publisher · View at Google Scholar · View at Scopus
  37. C. Ding, V. Parameswaran, L. Blizzard, J. Burgess, and G. Jones, “Not a simple fat-soluble vitamin: changes in serum 25-(OH)D levels are predicted by adiposity and adipocytokines in older adults,” Journal of Internal Medicine, vol. 268, no. 5, pp. 501–510, 2010. View at Publisher · View at Google Scholar · View at Scopus
  38. G. De Pergola, A. Ammirati, D. Caccavo, S. Bavaro, and G. Barone, “Vitamin D, obesity and risk of diabetes,” Nutritional Therapy and Metabolism, vol. 30, no. 2, pp. 59–66, 2012.
  39. B. J. Boucher, N. Mannan, K. Noonan, C. N. Hales, and S. J. W. Evans, “Glucose intolerance and impairment of insulin secretion in relation to vitamin D deficiency in East London Asians,” Diabetologia, vol. 38, no. 10, pp. 1239–1245, 1995. View at Publisher · View at Google Scholar · View at Scopus
  40. S. Kayaniyil, R. Vieth, R. Retnakaran et al., “Association of vitamin D with insulin resistance and β-cell dysfunction in subjects at risk for type 2 diabetes,” Diabetes Care, vol. 33, no. 6, pp. 1379–1381, 2010. View at Publisher · View at Google Scholar · View at Scopus
  41. A. M. Borissova, T. Tankova, G. Kirilov, L. Dakovska, and R. Kovacheva, “The effect of vitamin D3 on insulin secretion and peripheral insulin sensitivity in type 2 diabetic patients,” International Journal of Clinical Practice, vol. 57, no. 4, pp. 258–261, 2003. View at Scopus
  42. J. Nagpal, J. N. Pande, and A. Bhartia, “A double-blind, randomized, placebo-controlled trial of the short-term effect of vitamin D3 supplementation on insulin sensitivity in apparently healthy, middle-aged, centrally obese men,” Diabetic Medicine, vol. 26, no. 1, pp. 19–27, 2009. View at Publisher · View at Google Scholar · View at Scopus
  43. P. R. Von Hurst, W. Stonehouse, and J. Coad, “Vitamin D supplementation reduces insulin resistance in South Asian women living in New Zealand who are insulin resistant and vitamin D deficient-a randomised, placebo-controlled trial,” British Journal of Nutrition, vol. 103, no. 4, pp. 549–555, 2010. View at Publisher · View at Google Scholar · View at Scopus
  44. B. Maestro, J. Campión, N. Dávila, and C. Calle, “Stimulation by 1,25-dihydroxyvitamin D3 of insulin receptor expression and insulin responsiveness for glucose transport in U-937 human promonocytic cells,” Endocrine Journal, vol. 47, no. 4, pp. 383–391, 2000. View at Scopus