Benchmarking B-Cell Epitope Prediction with Quantitative Dose-Response Data on Antipeptide Antibodies: Towards Novel Pharmaceutical Product Development

Table 2

IEDB B-cell assay record counts of selection in Figure 1.

Method/technique	Total	Positive	Negative
Ab-dependent; Phagocytosis/opsonization	162	120	42
Antibody-dependent cellular cytotoxicity	42	34	8
Complement-dependent cytotoxicity	63	34	29
Enhancement/activation of antigen activity	21	10	11
Exacerbation of disease after treatment	185	93	92
Hypersensitivity	20	14	6
Ig-mediated histamine release	8	7	1
Induction of tolerance	66	51	15
Inhibition of Ab biological activity	17	12	5
Neutralization/inhibition of antigen activity	1995	1337	658
Protection after challenge	858	499	359
Protection from fertility	79	50	29
Reduction of disease after treatment	125	96	29
Survival after challenge	325	211	114
All of the above methods/techniques	3966	2568	1398