Intra-Amniotic LPS Induced Region-Specific Changes in Presynaptic Bouton Densities in the Ovine Fetal Brain

Figure 2

Photographs of synaptophysin immunoreactivity in the motor cortex. (a)–(c) Representative images of synaptophysin immunoreactive presynaptic boutons in the motor cortex (scale bar = 200 μm) of a control (a), a LPS2D animal (b), and a LPS14D animal (c). (d)–(f) Representative images of synaptophysin immunoreactive presynaptic boutons in the motor cortex layers 5-6 (scale bar = 200 μm) of a control (d), a LPS2D animal (e), and a LPS14D animal (f). Intra-amniotic LPS exposure significantly decreased synaptophysin staining in the motor cortex layers 5-6 compared to control animals (see also Figure 3(a)).

(a)

(b)

(c)

(d)

(e)

(f)