A Kinetic-Model-Based Approach to Identify Malfunctioning Components in Signal Transduction Pathways from Artificial Clinical Data

Table 1

The rank of the possibility of the reactions whose upregulation causes the abnormal profiles shown in Figure 6(a). is the similarity factor determined by (2) from the nuclear STAT3 dimer and SOCS3 profiles.

Rank	Reaction index		(STAT3N-STAT3N)	(SOCS3)
1	10	0.98	0.98	0.98
2	45	0.83	0.80	0.90
3	46	0.58	0.81	0.0012
4	47	0.57	0.80	0.0013
5	41	0.55	0.78	0.0016
6	35	0.12	0.11	0.18
7	40	0.11	0.0010	0.13
8	43	0.11	0.0010	0.13
9	12	0.10	0.080	0.16
10	9	0.079	0.063	0.13