Hepatitis C Virus Infection and Hospital-Related Outcomes: A Systematic Review

Ng, Michelle; Carrieri, Patrizia Maria; Awendila, Lindila; Socías, Maria Eugenia; Knight, Rod; Ti, Lianping

doi:https://doi.org/10.1155/2024/3325609

Canadian Journal of Gastroenterology and Hepatology

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Abstract Introduction Methods Results Discussion Limitations Conclusions Data Availability Disclosure Conflicts of Interest Authors’ Contributions Acknowledgments Supplementary Materials References Copyright Related Articles

Review Article | Open Access

Volume 2024 | Article ID 3325609 | https://doi.org/10.1155/2024/3325609

Hepatitis C Virus Infection and Hospital-Related Outcomes: A Systematic Review

Michelle Ng,¹Patrizia Maria Carrieri,²Lindila Awendila,³Maria Eugenia Socías,^1,4Rod Knight,^1,5and Lianping Ti^1,4

Academic Editor: Xingshun Qi

Received13 Jan 2022

Revised24 Oct 2023

Accepted12 Feb 2024

Published07 Mar 2024

Abstract

Background. People living with hepatitis C infection (HCV) have a significant impact on the global healthcare system, with high rates of inpatient service use. Direct-acting antivirals (DAAs) have the potential to alleviate this burden; however, the evidence on the impact of HCV infection and hospital outcomes is undetermined. This systematic review aims to assess this research gap, including how DAAs may modify the relationship between HCV infection and hospital-related outcomes. Methods. We searched five databases up to August 2022 to identify relevant studies evaluating the impact of HCV infection on hospital-related outcomes. We created an electronic database of potentially eligible articles, removed duplicates, and then independently screened titles, abstracts, and full-text articles. Results. A total of 57 studies were included. Analysis of the included studies found an association between HCV infection and increased number of hospitalizations, length of stay, and readmissions. There was less consistent evidence of a relationship between HCV and in-hospital mortality. Only four studies examined the impact of DAAs, which showed that DAAs were associated with a reduction in hospitalizations and mortality. In the 14 studies available among people living with HIV, HCV coinfection similarly increased hospitalization, but there was less evidence for the other hospital-related outcomes. Conclusions. There is good to high-quality evidence that HCV negatively impacts hospital-related outcomes, primarily through increased hospitalizations, length of stay, and readmissions. Given the paucity of studies on the effect of DAAs on hospital outcomes, future research is needed to understand their impact on hospital-related outcomes.

1. Introduction

Chronic hepatitis C virus (HCV) infection constitutes a major public health challenge, with an estimated 71 million people affected worldwide [1, 2]. People living with HCV have a significant impact on the global healthcare system, with high utilization rates of inpatient services [3, 4]. Between 2005 and 2014, hospitalizations involving HCV increased by 59.8% in the United States (US) and were associated with increased length of stay, a rise in average costs, and higher in-hospital mortality when compared to stays without HCV [5]. While it appears that traditional liver complications such as variceal bleeding and ascites have remained stable in recent years, nonliver complications such as infection (e.g., pneumonia, cellulitis, and urinary tract infections) and renal failure have increased among those hospitalized, perhaps reflecting the high proportion of comorbidities among those with HCV [6]. With inpatient services being responsible for two-thirds of the total economic costs of HCV, it is expected that the burden of chronic HCV infection on hospital systems will continue to be significant [7, 8].

The increasing burden of acute inpatient care for HCV is largely among those born between 1945 and 1965 [4, 5, 9]. According to US surveillance data, HCV-related hospitalizations were the highest among this “baby boomer” generation and 3 to 4 times the rate of other age groups [5]. Furthermore, hospitalizations in this group increased by 67.3% between 2005 and 2014, while they decreased in younger people living with HCV [5]. A large proportion of people with HCV tested positive prior to rigorous blood donation screening and are now of older age [10]. Advancing age and increased duration of infection parallel the slow onset and progression of HCV-related complications such as advanced liver disease [10–12].

Direct-acting antivirals (DAAs) have made widespread treatment of hepatitis C infection a feasible strategy [2, 13–15]. With high cure rates and proven efficacy in various populations, DAAs are an appealing approach to control this global epidemic and its expanding financial burden on acute care systems [8, 16]. An observational study in Italy found that antiviral treatment of HCV decreased hospitalization costs from 85% to 10% of total healthcare expenditure [8]. However, as of yet, there has not been a comprehensive review of the impact of HCV infection on hospital-related outcomes and how DAAs could influence these outcomes. While there is literature from the US suggesting increased hospitalizations in those with HCV infection, there has not been a review done in a systematic manner on a global scale. Additionally, there has been no previous systematic review or meta-analysis examining the role of HCV on hospital-related outcomes beyond hospitalization. Therefore, the purpose of this review was to comprehensively assess the literature to better understand the impact of HCV on hospital-related outcomes, including hospitalization rates, length of stay, leaving the hospital against medical advice, readmissions, and in-hospital mortality. When applicable, we separated findings that examined these outcomes among adults living with HCV/HIV coinfection. In addition, we aimed to explore the potential impact of DAAs on these outcomes.

2. Methods

We referred to the PRISMA and PRISMA-P (Preferred Reporting Items for Systematic Reviews and Meta-Analyses Protocols) Guidelines for the development of this systematic review [17, 18] (see Figure 1 for PRISMA flow diagram). The protocol is also documented in the PROSPERO database (CRD42017081082) [19].

2.1. Search Strategy

The search strategy was developed in consultation with a medical reference librarian at the University of British Columbia (U. Ellis, October 5, 2017, personal communication). We searched the following 5 electronic databases to identify relevant studies published from database inception to August 9, 2022: MEDLINE, EMBASE, CINAHL, PsycINFO, and Web of Science. Search terms were combined using appropriate Boolean operators and included terms relevant to hospital-related outcomes and HCV (see detailed strategy in S1 Table). We mapped the terms to database-specific headings and controlled vocabulary terms when available. We hand-searched reference lists of published literature reviews and included studies.

2.2. Eligibility Criteria

The population, exposure, outcomes, and study designs considered in this review are included in Table 1. Only English-language publications were eligible for inclusion, but we did not restrict eligibility to setting or publication date.

2.3. Study Selection, Data Extraction, and Synthesis

After the database search and removal of duplicates, two investigators (MN and LA) independently screened titles, abstracts, and full-text articles in three separate stages. At each stage, studies not clearly meeting inclusion criteria were excluded from further review. Disagreements were resolved by consensus, and, if required, discussion with a third investigator (LT). We extracted data using a standardized form, which was then synthesized narratively and in structured tables.

2.4. Risk of Bias Assessment

The methodological quality of the included studies was assessed using the Newcastle-Ottawa Scale (NOS) by two investigators (MN and LT) [20]. Studies were evaluated for risk of bias through assessment of selection bias (e.g., representativeness), comparability of groups (e.g., confounding factors), and assessment of outcome(s) (e.g., adequate follow-up).

3. Results

3.1. Summary of Included Studies

Of the 57 included studies (Figure 1), the majority (n = 41) were conducted in North America, while the remaining studies were conducted in Europe (n = 9), Asia (n = 3), Australia (n = 2), Africa (n = 1), and spanning multiple continents (n = 1). The studies were conducted between 1989 and 2019. The majority of studies employed a retrospective design (n = 44), while the remaining studies used a prospective (n = 9), cross-sectional (n = 3), or combined retrospective and prospective design (n = 1). There were 31 unique databases where data were drawn from. Databases that were utilized in more than 1 study included the Nationwide Inpatient Sample (n = 6), Medicare (n = 5), Healthcare Cost and Utilization Project (n = 2), HIV Research Network (n = 2), National Hospital Discharge Survey (n = 2), Spanish Minimum Basic Data Set (n = 2), and the US Renal Data System (n = 2). An additional 10 databases were used in 1 included study only. Fourteen studies were conducted among people living with HIV infection. Four available studies examined the impact of DAAs on hospital-related outcomes among people with HCV infection.

3.2. Risk of Bias within Studies/Quality Assessment

Most studies relied on anti-HCV serology (n = 12), HCV-RNA (n = 9), and International Classification of Diseases, Ninth and Tenth Revision, and Clinical Modification codes (n = 22) to define their HCV exposure variable. The remaining studies relied on self-report (n = 2), were not defined (n = 8), or examined DAAs as their exposure variable (n = 4). Overall, most studies had good methodological quality with a Newcastle-Ottawa Scale score of at least 6 (n = 49). Additional information on study location, design, population characteristics, exposure, outcome (s), and main findings are available in Tables 2 and 3. Study quality scores are available in Table 3.

3.3. Hospitalization

There were twenty-six available articles that examined the impact of HCV on hospitalization. Fourteen of these studies analyzed the effect of HCV mono-infection, while twelve studies looked at the effect of HCV coinfection among those living with HIV.

Of the fourteen articles that looked at the effect of HCV mono-infection on hospitalization, twelve studies showed evidence that people living with HCV infection are at an increased odds of hospitalization compared to those without HCV, with odds ratios ranging from 1.09 to 2.74 [23, 28–30, 34, 43, 45, 48, 54, 57, 67, 70]. For example, a retrospective study of commercially insured patients in the US (n = 17722) found that in a 1-year duration, those with HCV infection had 15.96% more hospitalizations compared to HCV-negative patients [57]. These findings of a positive association with HCV infection and hospitalization were consistent among other populations, including two US studies of renal and liver transplant recipients (n = 7220 and n = 28692, respectively) [34, 67] and one international study of patients receiving hemodialysis (n = 76689) [23] Similar results were seen in two studies focused on specific hospitalizations for infection and heart failure [30, 54]. The two other studies, which were cross-sectional surveys in Europe and the US, showed no statistically significant difference in annual hospitalization with HCV mono-infection when compared to matched controls [76, 77].

There were twelve studies conducted among people living with HIV infection, of which nine studies showed that HCV coinfection was associated with increased hospitalization, with incidence rate ratios ranging from 1.22 to 1.75 [22, 24, 25, 32, 40, 41, 60, 69, 75]. For example, a large US study of hospitalized patients with HIV (n = 263062) found that those with HCV coinfection had an increased hospitalization rate of 23.5 per 100 individuals, compared to 19.9 among those with HIV mono-infection [32]. These findings were consistent among populations with psychiatric illnesses [69]. The three other studies (two conducted in the US and one in Australia) failed to show a statistically significant difference in hospitalization with HCV coinfection [21, 46, 62].

Three studies were available that examined the impact of DAAs on hospitalization, of which all showed evidence that DAAs decrease hospitalization rates [50, 58, 66]. A retrospective study of patients with HCV infection and cirrhosis (n = 378) in the US found that DAA treatment was associated with a 64.3% reduction in liver-related hospitalizations [50].

3.4. In-Hospital Mortality

Of the thirteen studies that focused on HCV mono-infection and in-hospital mortality, seven of these studies found higher odds of in-hospital mortality among people living with HCV infection compared to those without HCV, with odds ratios ranging from 1.23 to 9.45 [37, 49, 55, 56, 65, 68, 71]. For example, a US study of Medicare patients (n = 273132) found that HCV infection increased the odds of in-hospital mortality by 23% [65]. Only one study showed decreased in-hospital mortality among patients with HCV infection. However, this US study of hospitalized patients with viral hepatitis (n = 1217165) compared the mortality rates of the HCV-exposed group to HBV as the control group [38]. Another retrospective study in Spain had variable results when examining intensive care unit (ICU) mortality and HCV infection, showing that HCV infection resulted in higher mortality only among those with severe sepsis and compensated cirrhosis, while subgroups without severe sepsis or with decompensated cirrhosis showed no difference in ICU mortality [31]. The four remaining studies showed no difference in in-hospital mortality between patients with and without HCV mono-infection across different populations, including two studies of US patients with alcohol-related diseases [52, 72], one study of Turkish patients undergoing cardiac surgery [33], and one study of patients from a Scottish liver database [70].

There were two studies conducted among people living with HIV infection [32, 59]. A retrospective study of ICU admissions in Spain (n = 1891) found increased mortality with HCV coinfection by 44% to 57%, regardless of whether severe sepsis was present [59]. Conversely, a US study of hospitalized patients (n = 263062) found no difference in mortality with HCV coinfection [32].

One study was available that examined the impact of DAAs on in-hospital mortality [66]. In this Canadian study of in-patients with chronic HCV and chronic liver disease over the period of 2004 to 2016, DAAs resulted in a 1.9% annual decrease in mortality [66].

3.5. Length of Stay (LOS)

Of the ten articles that looked at the effect of HCV mono-infection on LOS, nine studies showed evidence that people living with HCV infection have an increased LOS compared to those without HCV [43, 44, 47, 51, 55, 65, 70–72]. This ranged from an additional 0.85 days to 5.8 days when comparing average LOS. The majority of these studies were conducted in the US. A retrospective study of US Medicare patients (n = 273132) found that length of stay was increased by 41.54% among patients with HCV infection [65]. These findings were consistent with various other populations, including two studies among surgical patients [51, 55] and two studies among patients with alcohol-related diseases [71, 72]. In contrast, one study conducted in the US (n = 1217165) found that HCV infection decreased LOS by 0.64 days when compared to HBV infection [38].

Among the four studies conducted among people living with HIV infection, the effects of HCV coinfection on LOS were variable when compared to HIV mono-infection [22, 32, 46, 60]. A study of 842 patients from the Australian HIV observation database found that HCV coinfection increased LOS after multivariable analysis [46]. On the other hand, a large US study (n = 263062) found that HCV coinfection decreased LOS by 0.4 days [32]. The two other studies, conducted in a US AIDS primary care service and a single Spanish hospital, showed no statistical difference in LOS [22, 60].

3.6. Readmission

Of the eleven studies that focused on HCV mono-infection and readmission, nine of these studies found higher odds of readmission among people living with HCV infection compared to those without HCV, with odds ratios ranging from 1.1 to 2.37 [26, 27, 39, 42, 47, 55, 63, 73, 74]. One retrospective study of hospitalized inmates in the US (n = 4673) found that HCV infection increased readmission rates at 30 days by 73% [74]. Similar findings were seen among patients with cirrhosis, with two studies conducted in China (n = 3402) and the US (n = 69612) showing an increased likelihood of readmission with HCV infection [42, 73]. This positive association of HCV infection with readmission was also seen among other populations in North America, such as two studies of surgical patients [39, 55] and two studies of transplant recipients [27, 63]. The two other studies, drawn from a Scottish liver disease database and a US renal database, found no statistically significant difference in readmission with HCV mono-infection [53, 70].

There was one study conducted among people living with HIV infection. This was a retrospective study of inpatients (n = 1937) in a Spanish hospital, which found that HCV coinfection increased the risk of 30-day readmission by 10% [60].

One small study examined the impact of DAAs on readmission in a composite endpoint [36]. This single-center US study included 13 kidney transplant recipients with HIV/HCV coinfection and examined the rate of serious infections requiring ICU admission during initial transplant hospitalization or readmission within 6 months. They found that recipients in the DAA era had less serious infections when compared to those in the pre-DAA era (0% versus 67%, ). However, readmissions were not reported separately, therefore limiting conclusions on the specific effect of HCV on this outcome.

3.7. Discharge against Medical Advice

There was one study available that included discharge against medical advice as an outcome. This US study of hospitalizations with cirrhosis (n = 581380) found that patients with HCV infection as the etiology of liver disease were less likely to self-discharge by 13% when compared to those with non-HCV etiologies [61].

3.8. Other Hospital-Related Outcomes

There were three articles available that included in-hospital complications as an outcome, of which all three showed evidence that HCV infection was associated with higher odds of complications during hospitalization, with odds ratios ranging from 1.30 to 2.14 [35, 49, 51]. All three studies were conducted among US patients undergoing elective total joint arthroplasty.

One study examined the impact of HCV infection on medical ICU admissions among patients from the US Veterans Health Administration (n = 155550) and showed that HCV infection increased the risk of ICU admissions by 33% [64].

Another study assessed the impact of DAAs on ICU admissions. As described previously, this small US study of kidney transplant recipients with HIV/HCV coinfection found that recipients in the DAA era had lower rates of serious infections requiring ICU admission during initial transplant hospitalization or readmission within 6 months [36]. However, ICU admissions were not reported separately in their data.

4. Discussion

4.1. Summary of Evidence

Our systematic review found consistently good and high-quality evidence of an association between HCV infection and hospital-related outcomes, primarily increased hospitalizations, length of stay, and readmissions, with a less consistent association with increased in-hospital mortality. To our knowledge, there has been no previous systematic review on HCV infection and hospital outcomes. Our findings demonstrate that chronic HCV infection will continue to impact hospital care as the “baby boomer” cohort advances in age [5, 6, 78]. While there were few studies on DAAs available, those available showed that DAAs were associated with a reduction in hospitalizations and mortality [36, 50, 58, 66]. With the advancement of DAAs, there is growing potential for the widespread treatment of HCV to combat this epidemic and its financial burden on hospital systems [8, 16].

We found that the presence of HCV infection increased hospitalizations, length of stay, and readmissions, including among populations with other comorbidities, such as end-stage renal disease on hemodialysis, post-solid organ transplant, and psychiatric illness. These findings persisted even after the majority of studies had adjusted for a number of confounding variables, including age, sex, race, severity of liver dysfunction, and type and number of comorbidities, including HIV and substance use (e.g., injection drug use and alcohol use). A possible explanation for this may be that HCV infection is often considered a chronic issue and not prioritized by patients and their health-care providers as compared to other pressing issues (e.g., food and housing instability, cancer, cardiovascular disease, and renal disease) [79, 80]. One US study from the pre-DAA era found that many physicians do not address HCV treatment, especially in acute care settings where 64–80% of people diagnosed with HCV did not have a discussion about treatment with their diagnosing physician, compared to 36% diagnosed in the community by a generalist physician [81]. People with chronic HCV infection often have more comorbidities [82–84] and lower socioeconomic status [85], which in themselves are associated with worse hospital outcomes [86–89]. Chronic HCV infection, which is typically asymptomatic, would be less likely to be addressed in people who commonly present with complex medical and psychosocial issues, thereby resulting in the development of severe metabolic complications and negative hospital outcomes later on.

In the fourteen studies conducted among people living with HIV, we found that those with HCV coinfection similarly and consistently had increased hospitalizations. However, unlike our findings among those without HIV, there was less evidence of a consistent relationship for length of stay, in-hospital mortality, and readmissions. One possible explanation may be that differences in medical and psychosocial factors between those with and without HIV coinfection may affect their hospital visits [90–92]. In particular, given the increased effort to deliver HIV treatment globally [93], those with HIV coinfection may be more likely to be connected to health care compared to those without HIV infection. Multiple studies in North America have shown that HIV coinfection and being connected to health care such as through antiretroviral therapy or opioid agonist treatment were associated with higher treatment uptake for HCV [94–98]. Therefore, while HCV coinfection still led to increased hospitalizations among those living with HIV, regular engagement in health care may mitigate and be protective in regard to the other negative hospital outcomes examined in this systematic review.

There was very limited evidence that discussed the impact of DAAs on hospital outcomes, with only three studies found [50, 58, 66]. While the studies available showed that DAAs were associated with fewer hospitalizations and in-hospital mortality, this is an identified gap in knowledge. With the World Health Organization’s global targets for 2030 of having 80% of people on treatment, 90% of new infections reduced, and 65% reduction in mortality, it is clear that DAAs will play a prominent role in the global HCV strategy [2, 99]. There is a need for future studies to better understand the effects of DAAs on short- and long-term hospital-related outcomes and the reduction of associated costs. The majority of studies examining hospitalization did not describe the reason for admission (n = 23), and therefore, we are unable to conclude whether HCV cure with DAAs would significantly impact hospital outcomes in people with HCV as well as other comorbidities. Nevertheless, previous studies have consistently shown the benefits of DAAs for curing HCV, including among the most marginalized populations such as people who inject drugs [13, 95, 100]. Therefore, efforts to scale up access and uptake of these medications through interventions that account for individual, social, structural, and environmental influences are critical for ensuring equitable access.

5. Limitations

Several limitations should be considered when interpreting our findings. First, as most studies in our review were observational, we are unable to infer a causal association between HCV and negative hospital outcomes. While many of the studies reviewed used multivariable analyses, it is possible that our findings are due to unmeasured confounding. However, this is a common limitation of observational studies that is unlikely to be overcome, given the unethical nature of randomizing people to HCV infection. Furthermore, the study designs for most included studies were retrospective in nature, which could lead to biased results. Second, the variation in the definition of HCV infection limits our ability to make confident interpretations. While 21 studies used anti-HCV serology or HCV-RNA levels to define HCV infection as the exposure variable, the majority of studies relied on ICD codes or were undefined, causing uncertainty as to whether HCV infection was appropriately confirmed, or whether it was an acute or chronic infection. Third, the majority of studies were completed in high-income countries, with a significant portion among people with HIV coinfection, which may affect the generalizability of our results. Fourth, as with any review of literature, our findings are subject to publication bias, which may weigh results towards significance. Lastly, it is possible that we may have missed some pertinent literature in our search strategy, particularly non-English studies and conference abstracts. While screening and selection of studies are subjective, we attempted to minimize this bias by using two independent reviewers during the screening process.

6. Conclusions and Future Directions

In summary, this systematic review found good to high-quality evidence that HCV negatively impacts hospital outcomes, primarily through increased hospitalizations, length of stay, and hospital readmissions. There was a paucity of studies on the effect of DAAs on hospital outcomes. As DAAs become more available and accessible, future research is needed to understand their impact on hospital-related outcomes. [101].

Data Availability

The data that support the findings of this systematic are publicly available and included in the manuscript and supporting files.

Disclosure

Funders had no role in this review. PRISMA and PRISMA-P guidelines were followed in the development of this systematic review [17, 18].The protocol is also documented in the PROSPERO database (CRD42017081082) [19].

Conflicts of Interest

The authors declare that there are no conflicts of interest.

Authors’ Contributions

LT, PC, LA, and MN were responsible for the study design. LA and MN conducted data extraction. MN prepared the first draft of the manuscript. All authors have contributed to and agreed on the content of the manuscript.

Acknowledgments

LT and RK were supported by a Michael Smith Foundation for Health Research (MSFHR) Scholar Award. MES was supported by an MSFHR/St. Paul’s Foundation Scholar Award.

Supplementary Materials

S1 TABLE: search strategy in OVID Medline. (Supplementary Materials)

References

S. Blach, S. Zeuzem, M. Manns et al., “Global prevalence and genotype distribution of hepatitis C virus infection in 2015: a modelling study,” The Lancet Gastroenterology & Hepatology, vol. 2, no. 3, pp. 161–176, 2017.
View at: Publisher Site | Google Scholar
Who, “Global hepatitis report,” 2017, http://www.who.int/hepatitis/publications/global-hepatitis-report2017/en/.
View at: Google Scholar
W. C. Grant, R. R. Jhaveri, J. G. McHutchison, K. A. Schulman, and T. L. Kauf, “Trends in health care resource use for hepatitis C virus infection in the United States,” Hepatology, vol. 42, no. 6, pp. 1406–1413, 2005.
View at: Publisher Site | Google Scholar
J. W. Galbraith, J. P. Donnelly, R. A. Franco, E. T. Overton, J. B. Rodgers, and H. E. Wang, “National estimates of healthcare utilization by individuals with hepatitis C virus infection in the United States,” Clinical Infectious Diseases, vol. 59, no. 6, pp. 755–764, 2014.
View at: Publisher Site | Google Scholar
Q. Ngo-Metzger, I. Mabry-Hernandez, K. C. Heslin, A. J. Weiss, A. Mummert, and S. B. Arlene, “Characteristics of Inpatient Stays Involving Hepatitis C,” 2005, https://hcup-us.ahrq.gov/reports/statbriefs/sb232-Hepatitis-C-Hospital-Stays-Trends.jsp.
View at: Google Scholar
S. K. Asrani, L. Hall, M. Hagan et al., “Trends in chronic liver disease-related hospitalizations: a population-based study,” American Journal of Gastroenterology, vol. 114, no. 1, pp. 98–106, 2019.
View at: Publisher Site | Google Scholar
S. C. Gordon, P. J. Pockros, N. A. Terrault et al., “Impact of disease severity on healthcare costs in patients with chronic hepatitis C (CHC) virus infection,” Hepatology, vol. 56, no. 5, pp. 1651–1660, 2012.
View at: Publisher Site | Google Scholar
V. Perrone, D. Sangiorgi, S. Buda, and L. Degli Esposti, “Disease progression and health care resource consumption in patients affected by hepatitis C virus in real practice setting,” ClinicoEconomics and Outcomes Research, vol. 8, pp. 591–597, 2016.
View at: Publisher Site | Google Scholar
F. Xu, X. Tong, and A. J. Leidner, “Hospitalizations and costs associated with hepatitis C and advanced liver disease continue to increase,” Health Affairs, vol. 33, no. 10, pp. 1728–1735, 2014.
View at: Publisher Site | Google Scholar
M. Reid, J. C. Price, and P. C. Tien, “Hepatitis C virus infection in the older patient,” Infectious Disease Clinics of North America, vol. 31, no. 4, pp. 827–838, 2017.
View at: Publisher Site | Google Scholar
P. Pradat, N. Voirin, H. L. Tillmann, M. Chevallier, and C. Trépo, “Progression to cirrhosis in hepatitis C patients: an age-dependent process,” Liver International, vol. 27, no. 3, pp. 335–339, 2007.
View at: Publisher Site | Google Scholar
H. B. El‐Serag, J. Kramer, Z. Duan, and F. Kanwal, “Epidemiology and outcomes of hepatitis C infection in elderly US Veterans,” Journal of Viral Hepatitis, vol. 23, no. 9, pp. 687–696, 2016.
View at: Publisher Site | Google Scholar
R. Franco, J. W. Galbraith, E. T. Overton, and M. S. Saag, “Direct-acting Antivirals and Chronic Hepatitis C: Towards Elimination,” 2018, https://hrjournal.net/article/view/2923.
View at: Google Scholar
F. Conti, S. Brillanti, F. Buonfiglioli et al., “Safety and efficacy of direct-acting antivirals for the treatment of chronic hepatitis C in a real-world population aged 65 years and older,” Journal of Viral Hepatitis, vol. 24, no. 6, pp. 454–463, 2017.
View at: Publisher Site | Google Scholar
R. Maan, M. van Tilborg, K. Deterding et al., “Safety and effectiveness of direct-acting antiviral agents for treatment of patients with chronic hepatitis C virus infection and cirrhosis,” Clinical Gastroenterology and Hepatology, vol. 14, no. 12, pp. 1821–1830.e6, 2016.
View at: Publisher Site | Google Scholar
M. C. Roebuck and J. N. Liberman, “Assessing the burden of illness of chronic hepatitis C and impact of direct-acting antiviral use on healthcare costs in Medicaid,” American Journal of Managed Care, vol. 25, no. 8 Suppl, pp. S131–S139, 2019.
View at: Google Scholar
D. Moher, A. Liberati, J. Tetzlaff, and D. G. Altman, “Preferred Reporting Items for Systematic Reviews and Meta-Analyses: The PRISMA Statement,” 2009, https://www.bmj.com/content/339/bmj.b2535.
View at: Google Scholar
D. Moher, L. Shamseer, M. Clarke et al., “Preferred reporting items for systematic review and meta-analysis protocols (PRISMA-P) 2015 statement,” Systematic Reviews, vol. 4, no. 1, p. 1, 2015.
View at: Publisher Site | Google Scholar
L. Ti, M. Ng, L. Awendila, and P. M. Carrieri, “Hepatitis C virus infection and hospital-related outcomes: a systematic review protocol,” BMJ Open, vol. 8, no. 6, 2018.
View at: Publisher Site | Google Scholar
C. Luchini, B. Stubbs, M. Solmi, and N. Veronese, “Assessing the quality of studies in meta-analyses: advantages and limitations of the Newcastle Ottawa Scale,” World Journal of Meta-Analysis, vol. 5, no. 4, pp. 80–84, 2017.
View at: Publisher Site | Google Scholar
L. I. Gardner, R. S. Klein, L. A. Szczech et al., “Rates and risk factors for condition-specific hospitalizations in HIV-infected and uninfected women,” JAIDS Journal of Acquired Immune Deficiency Syndromes, vol. 34, no. 3, pp. 320–330, 2003.
View at: Publisher Site | Google Scholar
K. A. Gebo, M. Diener-West, and R. D. Moore, “Hospitalization rates differ by hepatitis C status in an urban HIV cohort,” JAIDS Journal of Acquired Immune Deficiency Syndromes, vol. 34, no. 2, pp. 165–173, 2003.
View at: Publisher Site | Google Scholar
D. A. Goodkin, B. Bieber, M. Jadoul, P. Martin, E. Kanda, and R. L. Pisoni, “Mortality, hospitalization, and quality of life among patients with hepatitis C infection on hemodialysis,” Clinical Journal of the American Society of Nephrology, vol. 12, no. 2, pp. 287–297, 2017.
View at: Publisher Site | Google Scholar
B. P. Linas, B. Wang, M. Smurzynski et al., “The impact of HIV/HCV co-infection on health care utilization and disability: results of the ACTG Longitudinal Linked Randomized Trials (ALLRT) Cohort,” Journal of Viral Hepatitis, vol. 18, no. 7, pp. 506–512, 2011.
View at: Publisher Site | Google Scholar
Á. Mena, H. Meijide, I. Rodríguez-Osorio, Á. Castro, and E. Poveda, “Liver-related mortality and hospitalizations attributable to chronic hepatitis C virus coinfection in persons living with HIV,” HIV Medicine, vol. 18, no. 9, pp. 685–689, 2017.
View at: Publisher Site | Google Scholar
M. Rezk and Z. Omar, “Deleterious impact of maternal hepatitis-C viral infection on maternal and fetal outcome: a 5-year prospective study,” Archives of Gynecology and Obstetrics, vol. 296, no. 6, pp. 1097–1102, 2017.
View at: Publisher Site | Google Scholar
N. Shankar, P. Marotta, W. Wall, M. Albasheer, R. Hernandez-Alejandro, and N. Chandok, “Defining readmission risk factors for liver transplantation recipients,” Gastroenterology and Hepatology, vol. 7, no. 9, pp. 585–590, 2011.
View at: Google Scholar
N. Tandon, K. R. Reddy, L. A. Balart et al., “Direct and indirect cost burden of chronic hepatitis C,” Am J Pharm Benefits, vol. 7, no. 4, pp. e90–e100, 2015.
View at: Google Scholar
E. H. Teshale, J. Xing, A. C. Moorman et al., “Higher all-cause hospitalization among patients with chronic hepatitis C: the Chronic Hepatitis Cohort Study (CHeCS),” Journal of Viral Hepatitis, vol. 23, no. 10, pp. 748–754, 2016.
View at: Publisher Site | Google Scholar
J. I. Tsui, M. A. Whooley, A. Monto, K. Seal, P. C. Tien, and M. Shlipak, “Association of hepatitis C virus seropositivity with inflammatory markers and heart failure in persons with coronary heart disease: data from the Heart and Soul study,” Journal of Cardiac Failure, vol. 15, no. 5, pp. 451–456, 2009.
View at: Publisher Site | Google Scholar
A. Álvaro-Meca, M. A. Jiménez-Sousa, A. Boyer et al., “Impact of chronic hepatitis C on mortality in cirrhotic patients admitted to intensive-care unit,” BMC Infectious Diseases, vol. 16, no. 1, p. 122, 2016.
View at: Publisher Site | Google Scholar
A. N. Ananthakrishnan, E. L. McGinley, J. Fangman, and K. Saeian, “Hepatitis C/HIV co-infection is associated with higher mortality in hospitalized patients with hepatitis C or HIV,” Journal of Viral Hepatitis, vol. 17, no. 10, pp. 720–729, 2010.
View at: Publisher Site | Google Scholar
C. Baran, M. Cakici, E. Ozcinar et al., “Clinical Results of Cardiac Surgery in Patients with Chronic Hepatitis C and Their Role in Risk Models: A Case-Control Study,” Thorac Cardiovasc Surg, vol. 66, 2018.
View at: Google Scholar
D. S. Batty, S. J. Swanson, A. D. Kirk, C. W. Ko, L. Y. Agodoa, and K. C. Abbott, “Hepatitis C virus seropositivity at the time of renal transplantation in the United States: associated factors and patient survival,” American Journal of Transplantation, vol. 1, no. 2, pp. 179–184, 2001.
View at: Publisher Site | Google Scholar
M. J. Best, L. T. Buller, A. K. Klika, and W. K. Barsoum, “Increase in perioperative complications following primary total hip and knee arthroplasty in patients with hepatitis C without cirrhosis,” The Journal of Arthroplasty, vol. 30, no. 4, pp. 663–668, 2015.
View at: Publisher Site | Google Scholar
J. F. Camargo, S. Anjan, N. Chin-Beckford et al., “Clinical outcomes in HIV+/HCV+ coinfected kidney transplant recipients in the pre- and post-direct-acting antiviral therapy eras: 10-Year single center experience,” Clinical Transplantation, vol. 33, no. 5, 2019.
View at: Publisher Site | Google Scholar
M.-F. Chen, L.-B. Jeng, and W.-C. Lee, “Surgical results in patients with hepatitis virus-related hepatocellular carcinoma in Taiwan,” World Journal of Surgery, vol. 26, no. 6, pp. 742–747, 2002.
View at: Publisher Site | Google Scholar
G. Cholankeril, R. B. Perumpail, M. Hu, G. Skowron, Z. M. Younossi, and A. Ahmed, “Chronic hepatitis B is associated with higher inpatient resource utilization and mortality versus chronic hepatitis C,” Digestive Diseases and Sciences, vol. 61, no. 9, pp. 2505–2515, 2016.
View at: Publisher Site | Google Scholar
R. Chowdhury, M. A. Chaudhary, D. J. Sturgeon et al., “The impact of hepatitis C virus infection on 90-day outcomes following major orthopaedic surgery: a propensity-matched analysis,” Archives of Orthopaedic and Trauma Surgery, vol. 137, no. 9, pp. 1181–1186, 2017.
View at: Publisher Site | Google Scholar
T. A. Crowell, K. A. Gebo, A. Balagopal et al., “Impact of hepatitis coinfection on hospitalization rates and causes in a multicenter cohort of persons living with HIV,” JAIDS Journal of Acquired Immune Deficiency Syndromes, vol. 65, no. 4, pp. 429–437, 2014.
View at: Publisher Site | Google Scholar
T. A. Crowell, S. A. Berry, J. A. Fleishman et al., “Impact of hepatitis coinfection on healthcare utilization among persons living with HIV,” JAIDS Journal of Acquired Immune Deficiency Syndromes, vol. 68, no. 4, pp. 425–431, 2015.
View at: Publisher Site | Google Scholar
J. Dai, J. Zhao, Y. Du, E. B. McNeil, and V. Chongsuvivatwong, “Biomarkers and sociodemographic factors predicting one-year readmission among liver cirrhosis patients,” Therapeutics and Clinical Risk Management, vol. 15, pp. 979–989, 2019.
View at: Publisher Site | Google Scholar
K. L. Davis, D. Mitra, J. Medjedovic, C. Beam, and V. Rustgi, “Direct economic burden of chronic hepatitis C virus in a United States managed care population,” Journal of Clinical Gastroenterology, vol. 45, no. 2, pp. e17–e24, 2011.
View at: Publisher Site | Google Scholar
R. Deshpande, M. Stepanova, P. Golabi, K. Brown, and Z. M. Younossi, “Prevalence, mortality and healthcare utilization among Medicare beneficiaries with Hepatitis C in Haemodialysis units,” Journal of Viral Hepatitis, vol. 26, no. 11, pp. 1293–1300, 2019.
View at: Publisher Site | Google Scholar
A. S. Duberg, H. Pettersson, S. Aleman et al., “The burden of hepatitis C in Sweden: a national study of inpatient care,” Journal of Viral Hepatitis, vol. 18, no. 2, pp. 106–118, 2011.
View at: Publisher Site | Google Scholar
K. Falster, H. Wand, B. Donovan et al., “Hospitalizations in a cohort of HIV patients in Australia, 1999–2007,” AIDS Lond Engl, vol. 24, no. 9, pp. 1329–1339, 2010.
View at: Publisher Site | Google Scholar
N. Fukui, P. Golabi, M. Otgonsuren, A. Mishra, C. Venkatesan, and Z. M. Younossi, “Demographics, resource utilization, and outcomes of elderly patients with chronic liver disease receiving hospice care in the United States,” American Journal of Gastroenterology, vol. 112, no. 11, pp. 1700–1708, 2017.
View at: Publisher Site | Google Scholar
H. F. Gidding, J. Amin, G. J. Dore, K. Ward, and M. G. Law, “Hospital-related morbidity in people notified with hepatitis C: a population-based record linkage study in New South Wales, Australia,” Journal of Hepatology, vol. 53, no. 1, pp. 43–49, 2010.
View at: Publisher Site | Google Scholar
L. Grau, E. Zachwieja, S. H. Summers et al., “Hepatitis C is an independent risk factor for perioperative complications and nonroutine discharge in patients treated surgically for hip fractures,” Journal of Orthopaedic Trauma, vol. 32, no. 11, pp. 565–572, 2018.
View at: Publisher Site | Google Scholar
L. A. Hill, R. J. Delmonte, B. Andrews et al., “Treatment of hepatitis C with direct-acting antivirals significantly reduces liver-related hospitalizations in patients with cirrhosis,” European Journal of Gastroenterology and Hepatology, vol. 30, no. 11, pp. 1378–1383, 2018.
View at: Publisher Site | Google Scholar
K. Issa, M. R. Boylan, Q. Naziri, D. C. Perfetti, A. V. Maheshwari, and M. A. Mont, “The impact of hepatitis C on short-term outcomes of total joint arthroplasty,” Journal of Bone and Joint Surgery American Volume, vol. 97, no. 23, pp. 1952–1957, 2015.
View at: Publisher Site | Google Scholar
W. R. Kim, J. B. Gross Jr, J. J. Poterucha, G. R. Locke 3rd, and E. R. Dickson, “Outcome of hospital care of liver disease associated with hepatitis C in the United States,” Hepatology, vol. 33, no. 1, pp. 201–206, 2001.
View at: Publisher Site | Google Scholar
E. A. King, L. M. Kucirka, M. McAdams-DeMarco et al., “Early hospital readmission after simultaneous pancreas-kidney transplantation: patient and center-level factors,” American Journal of Transplantation, vol. 16, no. 2, pp. 541–549, 2016.
View at: Publisher Site | Google Scholar
Y.-C. Lee, J.-L. Wang, Y.-H. Dong, H. C. Chen, L.-C. Wu, and C.-H. Chang, “Incidence of hospitalization for infection among patients with hepatitis B or C virus infection without cirrhosis in Taiwan: a cohort study,” PLoS Medicine, vol. 16, no. 9, 2019.
View at: Publisher Site | Google Scholar
S. A. Mahure, J. A. Bosco, J. D. Slover, J. Vigdorchik, R. Iorio, and R. Schwarzkopf, “Risk of complications after THA increases among patients who are coinfected with HIV and hepatitis C,” Clinical Orthopaedics and Related Research, vol. 476, no. 2, pp. 356–369, 2018.
View at: Publisher Site | Google Scholar
T. J. Marrie, G. J. Tyrrell, S. R. Majumdar, and D. T. Eurich, “Concurrent infection with hepatitis C virus and Streptococcus pneumoniae,” Emerging Infectious Diseases, vol. 23, no. 7, pp. 1118–1123, 2017.
View at: Publisher Site | Google Scholar
J. S. McCombs, Y. Yuan, J. Shin, and S. Saab, “Economic burden associated with patients diagnosed with hepatitis C,” Clinical Therapeutics, vol. 33, no. 9, pp. 1268–1280, 2011.
View at: Publisher Site | Google Scholar
S. A. McDonald, K. G. Pollock, S. T. Barclay et al., “Real-world impact following initiation of interferon-free hepatitis C regimens on liver-related outcomes and all-cause mortality among patients with compensated cirrhosis,” Journal of Viral Hepatitis, vol. 27, no. 3, pp. 270–280, 2019.
View at: Publisher Site | Google Scholar
J. Medrano, A. Álvaro-Meca, A. Boyer, M. A. Jiménez-Sousa, and S. Resino, “Mortality of patients infected with HIV in the intensive care unit (2005 through 2010): significant role of chronic hepatitis C and severe sepsis,” Critical Care, vol. 18, no. 4, p. 475, 2014.
View at: Publisher Site | Google Scholar
H. Meijide, Á. Mena, I. Rodríguez-Osorio et al., “Trends in hospital admissions, re-admissions, and in-hospital mortality among HIV-infected patients between 1993 and 2013: impact of hepatitis C co-infection,” Enfermedades Infecciosas Y Microbiología Clínica, vol. 35, no. 1, pp. 20–26, 2017.
View at: Publisher Site | Google Scholar
R. P. Myers, A. A. M. Shaheen, J. N. Hubbard, and G. G. Kaplan, “Characteristics of patients with cirrhosis who are discharged from the hospital against medical advice,” Clinical Gastroenterology and Hepatology, vol. 7, no. 7, pp. 786–792.e1, 2009.
View at: Publisher Site | Google Scholar
B. L. Norton, L. Park, L. J. McGrath, R. J. Proeschold Bell, A. J. Muir, and S. Naggie, “Health care utilization in HIV-infected patients: assessing the burden of hepatitis C virus coinfection,” AIDS Patient Care and STDs, vol. 26, no. 9, pp. 541–545, 2012.
View at: Publisher Site | Google Scholar
M. S. Patel, J. Mohebali, J. A. Shah, J. F. Markmann, and P. A. Vagefi, “Readmission following liver transplantation: an unwanted occurrence but an opportunity to act,” International Hepato-Pancreato-Biliary Association, vol. 18, no. 11, pp. 936–942, 2016.
View at: Publisher Site | Google Scholar
C. T. Rentsch, J. P. Tate, T. Steel et al., “Medical intensive care unit admission among patients with and without HIV, hepatitis C virus, and alcohol-related diagnoses in the United States: a national, retrospective cohort study,” JAIDS Journal of Acquired Immune Deficiency Syndromes, vol. 80, no. 2, pp. 145–151, 2019.
View at: Publisher Site | Google Scholar
M. Sayiner, M. Wymer, P. Golabi, J. Ford, I. Srishord, and Z. M. Younossi, “Presence of hepatitis C (HCV) infection in Baby Boomers with Medicare is independently associated with mortality and resource utilisation,” Alimentary Pharmacology & Therapeutics, vol. 43, no. 10, pp. 1060–1068, 2016.
View at: Publisher Site | Google Scholar
D. Schanzer, L. Pogany, J. Aho et al., “Impact of availability of direct-acting antivirals for hepatitis C on Canadian hospitalization rates, 2012-2016,” Canada Communicable Disease Report, vol. 44, no. 7/8, pp. 150–156, 2018.
View at: Publisher Site | Google Scholar
P. Sharma, N. P. Goodrich, D. E. Schaubel, A. R. Smith, and R. M. Merion, “National assessment of early hospitalization after liver transplantation: risk factors and association with patient survival,” Liver Transplantation, vol. 23, no. 9, pp. 1143–1152, 2017.
View at: Publisher Site | Google Scholar
A. K. Singal, Y. F. Kuo, and B. S. Anand, “Hepatitis C virus infection in alcoholic hepatitis: prevalence patterns and impact on in-hospital mortality,” European Journal of Gastroenterology and Hepatology, vol. 24, no. 10, pp. 1178–1184, 2012.
View at: Publisher Site | Google Scholar
M. St-Jean, H. Tafessu, K. Closson et al., “The syndemic effect of HIV/HCV co-infection and mental health disorders on acute care hospitalization rate among people living with HIV/AIDS: a population-based retrospective cohort study,” Canadian Journal of Public Health, vol. 110, no. 6, pp. 779–791, 2019.
View at: Publisher Site | Google Scholar
D. T. Steinke, T. L. Weston, A. D. Morris, T. M. MacDonald, and J. F. Dillon, “Epidemiology and economic burden of viral hepatitis: an observational population based study,” Gut, vol. 50, no. 1, pp. 100–105, 2002.
View at: Publisher Site | Google Scholar
P. J. Thuluvath, E. Ahn, and G. C. Nguyen, “Hepatitis C as a prognostic indicator among noncirrhotic patients hospitalized with alcoholic hepatitis,” Canadian Journal of Gastroenterology, vol. 27, no. 11, pp. 639–642, 2013.
View at: Publisher Site | Google Scholar
J. I. Tsui, M. J. Pletcher, E. Vittinghoff, K. Seal, and R. Gonzales, “Hepatitis C and hospital outcomes in patients admitted with alcohol-related problems,” Journal of Hepatology, vol. 44, no. 2, pp. 262–266, 2006.
View at: Publisher Site | Google Scholar
M. Wei, J. Ford, Q. Li et al., “Hospital cirrhosis volume and readmission in patients with cirrhosis in California,” Digestive Diseases and Sciences, vol. 63, no. 9, pp. 2267–2274, 2018.
View at: Publisher Site | Google Scholar
A. G. Wurcel, D. J. Burke, J. J. Wang et al., “The burden of untreated HCV infection in hospitalized inmates: a hospital utilization and cost analysis,” Journal of Urban Health, vol. 95, no. 4, pp. 467–473, 2018.
View at: Publisher Site | Google Scholar
M. K. Baum, D. T. Jayaweera, R. Duan et al., “Quality of life, symptomatology and healthcare utilization in HIV/HCV co-infected drug users in Miami,” Journal of Addictive Diseases, vol. 27, no. 2, pp. 37–48, 2008.
View at: Publisher Site | Google Scholar
A. C. El Khoury, J. Vietri, and G. Prajapati, “The burden of untreated hepatitis c virus infection: a US patients’ perspective,” Digestive Diseases and Sciences, vol. 57, no. 11, pp. 2995–3003, 2012.
View at: Publisher Site | Google Scholar
J. Vietri, G. Prajapati, and A. C. El Khoury, “The burden of hepatitis C in Europe from the patients’ perspective: a survey in 5 countries,” BMC Gastroenterology, vol. 13, no. 1, p. 16, 2013.
View at: Publisher Site | Google Scholar
S. Yin, L. Barker, E. H. Teshale, and R. B. Jiles, “Rising trends in emergency department visits associated with hepatitis C virus infection in the United States, 2006-2014,” Public Health Reports, vol. 134, no. 6, pp. 685–694, 2019.
View at: Publisher Site | Google Scholar
S. Cammarota, A. Citarella, A. Guida et al., “The inpatient hospital burden of comorbidities in HCV-infected patients: a population-based study in two Italian regions with high HCV endemicity (The BaCH study),” PLoS One, vol. 14, no. 7, 2019.
View at: Publisher Site | Google Scholar
T. M. Nápoles, A. W. Batchelder, A. Lin et al., “HCV treatment barriers among HIV/HCV co-infected patients in the US: a qualitative study to understand low uptake among marginalized populations in the DAA era,” Journal of Public Health, vol. 41, no. 4, pp. e283–e289, 2019.
View at: Publisher Site | Google Scholar
L. G. Rocca, B. P. Yawn, W. Peter, and W. Ray Kim, “Management of patients with hepatitis C in a community population: diagnosis, discussions, and decisions to treat,” The Annals of Family Medicine, vol. 2, no. 2, pp. 116–124, 2004.
View at: Publisher Site | Google Scholar
M. Lazo, C. Nwankwo, N. R. Daya et al., “Confluence of epidemics of hepatitis C, diabetes, obesity, and chronic kidney disease in the United States population,” Clinical Gastroenterology and Hepatology, vol. 15, no. 12, pp. 1957–1964.e7, 2017.
View at: Publisher Site | Google Scholar
C.-H. Liu, M.-L. Yu, C.-Y. Peng et al., “Comorbidities, concomitant medications and potential drug-drug interactions with interferon-free direct-acting antiviral agents in hepatitis C patients in Taiwan,” Alimentary Pharmacology & Therapeutics, vol. 48, no. 11–12, pp. 1290–1300, 2018.
View at: Publisher Site | Google Scholar
K. Büsch, J. Waldenström, M. Lagging et al., “Prevalence and comorbidities of chronic hepatitis C: a nationwide population-based register study in Sweden,” Scandinavian Journal of Gastroenterology, vol. 52, no. 1, pp. 61–68, 2017.
View at: Publisher Site | Google Scholar
L. H. Omland, M. Osler, P. Jepsen et al., “Socioeconomic status in HCV infected patients – risk and prognosis,” Clinical Epidemiology, vol. 5, pp. 163–172, 2013.
View at: Publisher Site | Google Scholar
P. Golabi, M. Otgonsuren, W. Suen, A. B. Koenig, B. Noor, and Z. M. Younossi, “Predictors of inpatient mortality and resource utilization for the elderly patients with chronic hepatitis C (CH-C) in the United States,” Medicine (Baltimore), vol. 95, no. 3, p. e2482, 2016.
View at: Publisher Site | Google Scholar
V. V. P. K. Mukthinuthalapati, S. Akinyeye, Z. P. Fricker et al., “Early predictors of outcomes of hospitalization for cirrhosis and assessment of the impact of race and ethnicity at safety-net hospitals,” PLoS One, vol. 14, no. 3, 2019.
View at: Publisher Site | Google Scholar
J. Hu, M. D. Gonsahn, and D. R. Nerenz, “Socioeconomic status and readmissions: evidence from an urban teaching hospital,” Health Affairs, vol. 33, no. 5, pp. 778–785, 2014.
View at: Publisher Site | Google Scholar
P. Vart, J. Coresh, L. Kwak, S. H. Ballew, G. Heiss, and K. Matsushita, “Socioeconomic status and incidence of hospitalization with lower-extremity peripheral artery disease: atherosclerosis risk in communities study,” Journal of the American Heart Association, vol. 6, no. 8, 2017.
View at: Publisher Site | Google Scholar
Commentary portion of U.S., “Surveillance data for viral hepatitis | CDC,” 2017, https://www.cdc.gov/hepatitis/statistics/2017surveillance/index.htm.
View at: Google Scholar
CDC, “HIV among people aged 50 and over | age | HIV by group | HIV/AIDS | CDC,” 2019, https://www.cdc.gov/hiv/group/age/olderamericans/index.html.
View at: Google Scholar
M. M. Denniston, R. B. Jiles, J. Drobeniuc et al., “Chronic hepatitis C virus infection in the United States, national health and nutrition examination survey 2003 to 2010,” Annals of Internal Medicine, vol. 160, no. 5, pp. 293–300, 2014.
View at: Publisher Site | Google Scholar
Who, “HIV/AIDS,” https://www.who.int/news-room/fact-sheets/detail/hiv-aids.
View at: Google Scholar
O. Falade-Nwulia, C. Suarez-Cuervo, D. R. Nelson, M. W. Fried, J. B. Segal, and M. S. Sulkowski, “Oral direct-acting agent therapy for hepatitis C virus infection: a systematic review,” Annals of Internal Medicine, vol. 166, no. 9, p. 637, 2017.
View at: Google Scholar
K. R. Hochstatter, L. J. Lauren J Stockman, H. Ryan et al., “The continuum of hepatitis C care for criminal justice involved adults in the DAA era: a retrospective cohort study demonstrating limited treatment uptake and inconsistent linkage to community-based care,” Health Justice, vol. 5, no. 1, p. 10, 2017.
View at: Google Scholar
M. Eugenia Socías, L. Ti, E. Wood et al., “Disparities in uptake of direct-acting antiviral therapy for hepatitis C among people who inject drugs in a Canadian setting,” Liver International, vol. 39, no. 8, pp. 1400–1407, 2019.
View at: Google Scholar
J. L. Marcus, L. B. Hurley, C. Scott et al., “Disparities in initiation of direct-acting antiviral agents for hepatitis C virus infection in an insured population,” Public Health Reports, vol. 133, no. 4, pp. 452–460, 2018.
View at: Google Scholar
M. Eugenia Socías, L. Ti, H. Dong et al., “High prevalence of willingness to use direct-acting antiviral-based regimens for hepatitis C virus (HCV) infection among HIV/HCV coinfected people who use drugs,” HIV Medicine, vol. 18, no. 9, pp. 647–654, 2017.
View at: Google Scholar
V. Calvaruso, S. Petta, and A. Craxì, “Is global elimination of HCV realistic?” Liver International, vol. 38, no. 1, pp. 40–46, 2018.
View at: Google Scholar
G. J Dore, F. Altice, A. H. Litwin et al., “Elbasvir-grazoprevir to treat hepatitis C virus infection in persons receiving opioid agonist therapy: a randomized trial,” Annals of Internal Medicine, vol. 165, no. 9, pp. 625–634, 2016.
View at: Google Scholar
N. Kronfli, N. Roy, J. Cox et al., “Canadian Co-Infection Cohort Study. Previous incarceration impacts access to hepatitis C virus (HCV) treatment among HIV-HCV co-infected patients in Canada,” Journal of the International AIDS Society, vol. 21, no. 11, 2018.
View at: Google Scholar

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