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Evidence-Based Complementary and Alternative Medicine
Volume 2012 (2012), Article ID 256561, 15 pages
http://dx.doi.org/10.1155/2012/256561
Research Article

Evaluation of the Chinese Medicinal Herb, Graptopetalum paraguayense, as a Therapeutic Treatment for Liver Damage in Rat Models

1Institute of Systems Biology and Bioinformatics, National Central University, Jhongli City 32001, Taiwan
2Graduate Institute of Microbiology and Public Health, National Chung Hsing University, Taichung 40227, Taiwan
3Division of Molecular and Genomic Medicine, National Health Research Institutes, Miaoli County, Zhunan 35053, Taiwan
4Biomarker Technology Development Division, Biomedical Technology and Device Research Labs, Industrial Technology Research Institute, Hsinchu 31040, Taiwan
5Center for Translational Research in Biomedical Sciences, Kaohsiung Chang Gung Memorial Hospital, Kaohsiung 83301, Taiwan
6Department of Education and Research, Taichung Veterans General Hospital, Taichung 40705, Taiwan
7Institute of Biopharmaceutical Sciences, National Yang-Ming University, Taipei 11221, Taiwan
8National Yang-Ming University-VGH Genome Research Center, Taipei 11221, Taiwan

Received 1 February 2012; Accepted 9 April 2012

Academic Editor: William C. S. Cho

Copyright © 2012 Li-Jen Su et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Supplementary Material

Supplementary Figure 1: Down-regulated expression of peroxisome proliferator-activated receptor, gamma (Pparg) was found in DMN-treated rat liver, consistent with the hypothesis that down regulation of Pparg may be connected to liver inflammation and fibrosis mechanisms. Microarray and Q-RT-PCR results indicated that Pparg expression recovered after GP treatment, suggesting potential for protecting or preventing liver damage.

Supplementary Figure 2: Rats in the DMN-damaged group treated with GP fared much better than those treated with Silymarin, especially in the sixth week by hierarchical clustering analysis.

Supplementary Table: Statistical analysis indicates that these 168 genes might serve as therapeutic target genes and GP could regulate the gene expression patterns better than Silymarin.

  1. Supplementary Figure 1
  2. Supplementary Figure 2
  3. Supplementary Table