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Evidence-Based Complementary and Alternative Medicine
Volume 2012 (2012), Article ID 519031, 15 pages
http://dx.doi.org/10.1155/2012/519031
Research Article

A Systems Biology Approach to Uncovering Pharmacological Synergy in Herbal Medicines with Applications to Cardiovascular Disease

1Center of Bioinformatics, College of Life Science, Northwest A&F University, Yangling, Shaanxi 712100, China
2School of Chemical Engineering, Dalian University of Technology, Dalian, Liaoning 116024, China
3Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing 100700, China
4Laboratory of Pharmaceutical Resource Discovery, Dalian Institute of Chemical Physics, Chinese Academy of Sciences, Dalian 116023, China

Received 19 August 2012; Accepted 10 October 2012

Academic Editor: Kashmira Nanji

Copyright © 2012 Xia Wang et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Citations to this Article [9 citations]

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  • Bo Zhang, Xu Wang, and Shao Li, “An Integrative Platform of TCM Network Pharmacology and Its Application on a Herbal Formula, Qing-Luo-Yin,” Evidence-Based Complementary and Alternative Medicine, vol. 2013, pp. 1–12, 2013. View at Publisher · View at Google Scholar
  • Gui-biao Zhang, Qing-ya Li, Qi-long Chen, and Shi-bing Su, “Network Pharmacology: A New Approach for Chinese Herbal Medicine Research,” Evidence-Based Complementary and Alternative Medicine, vol. 2013, pp. 1–9, 2013. View at Publisher · View at Google Scholar
  • Ming Yang, Jia-Lei Chen, Li-Wen Xu, and Guang Ji, “Navigating Traditional Chinese Medicine Network Pharmacology and Computational Tools,” Evidence-Based Complementary and Alternative Medicine, vol. 2013, pp. 1–23, 2013. View at Publisher · View at Google Scholar
  • Pei-Pei Wang, Du-Juan Xu, Can Huang, Wei-Ping Wang, and Wen-Ke Xu, “Astragaloside IV reduces the expression level of P-glycoprotein in multidrug resistant human hepatic cancer cell lines,” Molecular Medicine Reports, vol. 9, no. 6, pp. 2131–2137, 2014. View at Publisher · View at Google Scholar
  • Chunli Zheng, Jinan Wang, Jianling Liu, Mengjie Pei, Chao Huang, and Yonghua Wang, “System-level multi-target drug discovery from natural products with applications to cardiovascular diseases,” Molecular Diversity, 2014. View at Publisher · View at Google Scholar
  • Asfar S. Azmi, and Ramzi M. Mohammad, “Rectifying cancer drug discovery through network pharmacology,” Future Medicinal Chemistry, vol. 6, no. 5, pp. 529–539, 2014. View at Publisher · View at Google Scholar
  • Jinlong Ru, Peng Li, Jinan Wang, Wei Zhou, Bohui Li, Chao Huang, Pidong Li, Zihu Guo, Weiyang Tao, Yinfeng Yang, Xue Xu, Yan Li, Yonghua Wang, and Ling Yang, “TCMSP: a database of systems pharmacology for drug discovery from herbal medicines,” Journal of Cheminformatics, vol. 6, 2014. View at Publisher · View at Google Scholar
  • Peng Li, Jianxin Chen, Jinan Wang, Wei Zhou, Xia Wang, Bohui Li, Weiyang Tao, Wei Wang, Yonghua Wang, and Ling Yang, “Systems pharmacology strategies for drug discovery and combination with applications to cardiovascular diseases,” Journal of Ethnopharmacology, vol. 151, no. 1, pp. 93–107, 2014. View at Publisher · View at Google Scholar