Ameliorating Adriamycin-Induced Chronic Kidney Disease in Rats by Orally Administrated Cardiotoxin from Naja naja atra Venom
Figure 5
The effects of cardiotoxin on renal pathology. The treatment on rats was carried out as described in the legend of Figure 2. All rats were sacrificed after treatment for 6 weeks. The kidney was removed to make paraffin slices. (a, d, g, j, and m) showed that kidney slices stained with hematoxylin and eosin (HE). (b, e, h, k, and n) showed that kidney slices stained with Masson’s trichrome. (c, f, i, l, and o) showed that kidney slices stained with periodic acid-Schif (PAS). (a, b, and c) showed the change of renal pathology in normal control group; (d, e, and f) showed the change of renal pathology in adriamycin nephropathy group. Renal pathology in treatment groups with cardiotoxin at the dose of 45 g/kg (g, h, and i), 90 g/kg (j, k, and l), and 180 g/kg (m, n, and o) can been seen, respectively. Yellow arrow showed fatty degeneration, red arrow showed inflammatory cell infiltration, green arrow showed leakage protein in tubular lumen, and black arrow showed glomerular basement membrane (GBM) thickening and tubular interstitial fibrosis.
