Topical Antinociceptive Effect of Vanillosmopsis arborea Baker on Acute Corneal Pain in Mice

Table 2

(a) Effect of topical EOVA on formalin test in mice. (b) Effect of oral EOVA on formalin test in mice.

(a)

Group	Dose; (mg/kg)	Paw licking time (s)
		1st phase	2nd phase
Control	—	99.63±5.95	41.75±8.07
EOVA	25	106.8±10.03	19.67±8.83^∗∗∗∗
	50	81.83±6.53^∗∗∗∗	4.66±4.27^∗∗∗∗
	100	42.17±8.63^∗∗∗∗	18.33±6.83^∗∗∗∗
	200	26.75±2.52^∗∗∗∗	24.83±4.36^∗∗∗∗
Morphine	7.5	19.83±4.33^∗∗∗∗	13.83±4.56^∗∗∗∗

Data are expressed as mean ± s.e.m. ^∗∗∗∗𝑃<0.0001 compared to control group. ANOVA followed by Student-Newman-Keuls test.

(b)

Group	Dose; (mg/kg)	Paw licking time (s)
		1st phase	2nd phase
Control	—	57.67±1.89	96.17±6.95
EOVA	25	32.00±6.27^∗∗∗∗	49.33±7.96^∗∗∗∗
	50	38.50±4.23^∗∗∗∗	45.50±9.78^∗∗∗∗
	100	34.83±5.81^∗∗∗∗	36.50±11.43^∗∗∗∗
	200	37.50±4.08^∗∗∗∗	23.17±10.51^∗∗∗∗
Morphine	7.5	19.83±4.33^∗∗∗∗	13.83±4.56^∗∗∗∗

Data are expressed as mean ± s.e.m. ^∗∗∗∗𝑃<0.0001 compared to control group. ANOVA followed by Student-Newman-Keuls test.