Topical Antinociceptive Effect of Vanillosmopsis arborea Baker on Acute Corneal Pain in Mice

Table 3

(a) Effect of topically applied EOVA on the corneal nociception induced by a local application of a 5 M NaCl solution in mice. (b) Effect of orally administered EOVA on the corneal nociception induced by a local application of a 5 M NaCl solution in mice.

(a)

Group	Dose; (mg/kg)	Number of eye wipes (30 s)
Control	—	20.33±0.66
EOVA	25	15.33±0.91^∗∗∗
	50	16.67±0.84^∗∗
	100	16.67±0.66^∗∗
	200	14.33±0.61^∗∗∗∗
Morphine	7.5	12.17±0.83^∗∗∗∗

Data are expressed as mean ± s.e.m. ^∗∗𝑃<0.01, ^∗∗∗𝑃<0.001, and
^∗∗∗∗𝑃<0.0001 compared to control group. ANOVA followed by Student-Newman-Keuls test.

(b)

Group	Dose; (mg/kg)	Number of eye wipes (30 s)
Control	—	22.13±1.31
EOVA	25	16.50±1.26^∗∗
	50	14.75±0.70^∗∗∗
	100	15.25±1.09^∗∗∗
	200	12.63±0.73^∗∗∗
Morphine	7.5	11.88±0.83^∗∗∗

Data are expressed as mean ± s.e.m. ^∗∗𝑃<0.01, ^∗∗∗𝑃<0.001, and
^∗∗∗∗𝑃<0.0001 compared to control group. ANOVA followed by Student-Newman-Keuls test.