A Guided Tour of the Structural Biology of Gaucher Disease: Acid-β-Glucosidase and Saposin C
Figure 6
Loop 1 extended and helical conformations: interior view. (a) Extended conformation, overlay of sulfate-bound, glycerol-bound, and CBE-bound coordinates in this region. (b) Helical conformation using coordinates of IFG-bound GCase, NB-DNJ, and NB-DNJ. (c) N370S-mutant GCase. (d) apo-GCase. Dashed lines and color schemes are the same as in Figure 3.
