| Treatment | Regimen | High clarithromycin resistance area | Low clarithromycin resistance area |
| Standard triple therapy | A PPI (standard dose, b.i.d.), clarithromycin (500 mg, b.i.d.), and amoxicillin (1 g, b.i.d.) for 7–14 days | x | V |
| Bismuth-containing quadruple therapy | A PPI (standard dose, b.i.d.), bismuth (standard dose, q.i.d.), tetracycline (500 mg, q.i.d.), and metronidazole (250 mg, q.i.d.) for 10–14 days | V | V |
| Sequential therapy | A 5-day dual therapy with a PPI (standard dose, b.i.d.) and amoxicillin (1 g, b.i.d.) followed by a 5-day triple therapy with a PPI (standard dose, b.i.d.), clarithromycin (500 mg, b.i.d.), and metronidazole (500 mg, b.i.d.) | V | V |
| Concomitant therapy | A PPI (standard dose, b.i.d.), clarithromycin (500 mg, b.i.d.), amoxicillin (1 g, b.i.d.), and metronidazole (500 mg, b.i.d.) for 7–10 days | V | V |
| Levofloxacin-based triple therapy | A PPI (standard dose, b.i.d.), levofloxacin (500 mg, q.d.), and amoxicillin (1 g, b.i.d.) for 10 days | V | —* |
| Hybrid therapy | A 7-day dual therapy with a PPI (standard dose, b.i.d.) and amoxicillin (1 g, b.i.d.) followed by a 7-day quadruple therapy with a PPI (standard dose, b.i.d.), amoxicillin (1 g, b.i.d.), clarithromycin (500 mg, b.i.d.), and metronidazole (500 mg, b.i.d.) | V | V |
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