Staging of Alzheimer's Pathology in Triple Transgenic Mice: A Light and Electron Microscopic Analysis

Figure 4

Schematic drawings showing the distribution of Alz50-ir neurons at 3-week, 2-, and 5-month-old transcardially-fixed 3xTg-AD mice. Alz50-ir neurons were found mainly in the CA1 ventral hippocampus at 3 weeks of age. Note the increase in the number of Alz50-ir hippocampal neurons in the 2- and 5-month old mutant mice. In addition there was an age-related increase in Alz-50 positive neurons within the BLA. Abbreviations are the same as in Figure 2. Small dots = 1–5 positive neurons, medium-size dots = 10–20 positive neurons, and large dots = 100 positive neurons.