Review Article
Link between Aluminum and the Pathogenesis of Alzheimer's Disease: The Integration of the Aluminum and Amyloid Cascade Hypotheses
Table 2
Al-induced conformational changes of various proteins.
| Proteins | References |
| Disease-related proteins | | Alzheimer’s disease | | AP (1-40) | [64, 131–134] | DAEFRHDSGYEVHHQKLVFFAEDVGSNKGAIIGLMVGGVV | | AP (1-42): | [135, 136] | DAEFRHDSGYEVHHQKLVFFAEDVGSNKGAIIGLMVGGVVIA | | AP (25-35): | [137] | GSNKGAIIGLMV | | APP | [138] | Tau or hyperphosphorylated tau (PHF-tau) | [32, 57, 139] | Perkinson’s disease and other diseases with Lewy body | | -synuclein (NACP) | [140, 141] | Type 2 diabetes mellitus | | Amylin: | [142] | KCNTATCATQRLANFLVHSSNNFGAILSSTNVGSNTY | | Familial British dementia | | ABri: | [143] | ASNCPAIRHPGNKPAVGTLICSRTVKKNIIGGN | | Spinocerebellar ataxia | | Ataxin 3 | [144] | Dialysis-related arthropathy | | -microglobulin | [145] |
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