Protein Kinase C-Regulated Aβ Production and Clearance
Figure 2
Overexpression of PKCε reduces the amyloid plaque burden and inhibits Aβ accumulation in brain parenchyma. (a) Thioflavin S staining and anti-Aβ immunostaining revealed fewer plaques and Aβ immunoreactive deposits in the hippocampus and neocortex in APPInd/PKCε Tg1 mice than in APPInd mice. Scale bar: 200 μm. Quantification of (b) thioflavin S staining and (c) Aβ deposits in hippocampus and cortex sections (adapted from [14]). by two-tailed -test.
