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International Journal of Family Medicine
Volume 2012 (2012), Article ID 842912, 8 pages
Prevalent Obstacles and Predictors for People Living with Type 2 Diabetes
Department of Policlinic and Family Medicine, University of Tartu, L. Puusepa 1a, 50406 Tartu, Estonia
Received 7 August 2012; Revised 19 October 2012; Accepted 20 October 2012
Academic Editor: Janko Kersnik
Copyright © 2012 L. Pilv et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Background. Type 2 diabetes (T2DM) is a chronic, progressive disease with serious micro- and macrovascular complications. A person affected by T2DM should learn to accept the new restricted lifestyle. Aims. The aim of the study was to identify the prevalence of obstacles in coping with daily life for people with T2DM and the magnitude of the relationships of the obstacles with various patient characteristics. Methods. Participants were recruited from randomly selected GPs’ lists in Estonia. Respondents completed the Estonian version of the Diabetes Obstacles Questionnaire (DOQ). The statements were assessed on a 5-point scale. Biomedical and clinical variables were measured. The central tendency statistics and skewness and kurtosis for all statements were computed to find out those that reflect obstacles. Then obstacles of the DOQ were stratified. Multinomial logistic regression (MLR) was computed to estimate the influences of descriptive variables on the statements. Results and Conclusions. Altogether, 138 diabetic patients were enrolled in the study. Fourteen statements were identified as obstacles. Variables such as age, type of diabetes treatment, and BMI had significant effects on five of them. Younger age, BMI, and insulin nonuse were revealed as the strongest predictive characteristics for perceiving obstacles more often in coping with daily life.
Type 2 diabetes (T2DM) is a chronic, progressive disease with serious micro- and macrovascular complications. Diabetes has a twofold additional risk, independent of other conventional risk factors, of developing a life-threatening vascular disease [1, 2]. It has been proved that effective diabetes control can prevent or delay progression of complications and reduce the death rate of T2DM . However, although the latest guidelines for managing T2DM offer the best advice, treatment results are continuously poor. According to many authors, the main reason is the low adherence of patients to medical recommendations and, consequently, failure to achieve the therapeutic goals of their treatment [4–8]. During several past decades, a growing body of literature has been devoted to the investigation of the reasons for nonadherence. Numerous studies have attempted to analyze the relationships between adherence to medical advice and demographic, psychological, social, cognitive, and cultural factors between the healthcare provider and the medical system and between the disease and its treatment [9–11].
Although it is known that adherence to treatment is closely linked to T2DM patients’ ability to cope with daily life, not enough attention has been given to this complex area. In comparison, the devotion to the study of relationships between physician and a patient is considerably higher . It has been demonstrated that patients have many fears and they are afraid to follow all treatments recommended as necessarily in their best interests [13, 14]. Previous research has identified and described some self-perceptions and disease impacts on the daily life of patients [15–17]. However, these studies have not identified which of the patients’ characteristics may have an effect on the burden in everyday life. UK and Belgian studies which used the DOQ validated the questionnaire and showed a correlation between subscales relating to management of T2DM and HbA1c, but were not intended to detect predictors for obstacles [18, 19].
According to Vermeire et al. (2001), “if there is a desire to improve adherence, then research should primarily be based on a closer understanding of patients’ experience of their illness and medication rather than on the perceptions and expectations of healthcare professionals .” It is of the utmost importance of attaining a greater clarity of the most severe disease-related obstacles and of the factors influencing it.
We aimed to identify the prevalence of obstacles in coping with daily life for persons with T2MD from their perspective. That mainly involved finding out the possible predictors and patients’ characteristics which may have an effect on these burdens in everyday life. In doing so, this would enable healthcare professionals to understand the patients’ needs and fears and to provide helpful guidance.
2. Research Design and Methods
A questionnaire survey to research burdens and obstacles in living with T2DM was conducted in May to November 2009 in Estonia. Patient assessments were measured using the Diabetes Obstacles Questionnaire (DOQ).
The DOQ was developed to measure quantitatively the occurrence and prevalence of obstacles in coping with everyday life for diabetes patients. It was based on a comprehensive study of the literature  and the results of the metaethnology study EUROBSTACLE. EUROBSTACLE—an international aggregated qualitative research—was carried out in seven different European countries . The results have been described elsewhere .
The DOQ comprises 78 statements related to eight themes (see the appendix). The statements express impacts on the everyday life of T2DM patients, such as course of diabetes (diagnosis, medical treatment, self-monitoring, and lifestyle changes), person and context, knowledge and beliefs, and relationships with healthcare provider. The Estonian version of the questionnaire was validated through translating the English version into Estonian and back into English.
The participants of this study were recruited from the GPs’ lists in Estonia. Here, 741 GPs are members of the Association of Family Doctors, which makes up approximately 77% of all GPs and is the largest database of GPs in Estonia.
Eighty GPs were randomly selected from the list of the Estonian Association of Family Doctors and invited by e-mail to participate in the study. Forty-six of them (response rate 58%) agreed to recruit patients with a T2DM diagnosis, involving all types of diabetes treatment. The researchers from six participating countries (Belgium, Estonia, France, Serbia, Slovenia, and Turkey) decided on the study design of three to five consecutive patients. At the same time a similar study was carried out in all of these countries which allows a comparison of the data across the participating countries. GPs in Estonia recruited five consecutive eligible T2DM patients during their routine visit. They received a study kit including an information leaflet, an Estonian version of the DOQ, and an extract from their records with their latest clinical results, obtained no later than the previous year, and data about complications. A total of 230 questionnaires were sent to the GPs; 149 patients completed and returned the questionnaires by mail to the researchers (response rate 64.8%). The GPs and patients reasons for declining to participate were not studied in detail. Eleven patient responses were excluded from analysis because the GPs had sent extracts from their records under a separate cover. As the completed DOQs were anonymous, it was impossible to match them to the clinical data provided by the GPs. The final number of responses was 138.
Descriptive characteristics concerning age, sex, weight, height, BMI, smoking status, and disease-related variables such as glycaemic control (HbA1c), total cholesterol (Chol), low-density cholesterol (LDL-c), high-density cholesterol (HDL-c), blood pressure (BP), type of diabetic treatment, and occurrence of complications such as microangiopathy, macroangiopathy, “diabetic foot,” nephropathy, and neuropathy were studied. The frequency and percentages for categorical variables and mean, standard error of the mean, standard deviation, minimum and maximum for all quantitative variables were then computed.
The statements were assessed on a 5-point scale, graded in the questionnaire as 5 = “Strongly Agree,” 4 = “Agree,” 3 = “Neutral,” 2 = “Disagree,” and 1 = “Strongly Disagree.” The central tendency statistics and skewness and kurtosis for all statements were computed. We wanted to find out the statements that were agreed by a higher proportion of the respondents as burdens in everyday life concerning their disease. We picked the statements that corresponded to the following three criteria and defined these for “obstacles”: mode “Agree”, mean higher than 3.0, and negative skewness. Several obstacles did not show any natural ordering distribution to the values. By using multinomial logistic regression (MLR) we intended to check if any of the patients’ characteristics could predict burdens. In this MLR, only the defined obstacles were used as dependent variables. Since no a priori hypothesis had been made to determine the order of entry of independent variables, all descriptive characteristics except “smoking status” were included in the analysis as independent variables. “Smoking status” encompassed 15 (10.9%) missing values.
Stratification of the dependent variable for MLR was made according to the given answers: 2 = “Strongly Agree” and “Agree” with the obstacle, 1 = “Neutral,” and 0 = “Disagree” and “Strongly Disagree” with the obstacle. We made “0” a reference category, and all parameters in the model were interpreted in reference to it. We used a backward stepwise elimination model. Parameter coefficients, asymptotic covariance and correlation matrices, likelihood-ratio tests for model and partial effects, Pearson and deviance chi-square goodness of fit, Cox and Snell, Nagelkerke, and McFadden , and classification tables were all studied. The odds ratios with 95% confidence interval for variables predictors that significantly contribute to the model were computed. Means with SD for covariates and frequencies for categorical parameters were calculated to clarify whether a predictor decreased or increased the likelihood of that response category with respect to the reference category. Statistical results were considered significant at .
All quantitative data were analyzed using the IBM SPSS Statistics Version 20.
In the study group of 138 participants, the mean age was 66.7 (±9.8) years and the mean duration of T2DM was 8.6 (±5.1) years. Of the participants, 45% were male. The descriptive characteristics of whole sample are presented in Table 1.
Nephropathy and macrovascular complications appeared most frequently.
Latest clinical results were HbA1c 7.1 (±1.2); Chol 5.2 mmol (±1.1) but showed a considerable range. The clinical results of the sample are presented in Table 2.
3.1. Prevalent Obstacles
The statistically significant majority of the respondents did not recognize most statements of the DOQ as obstacles ( out of 78). Only a few items () were consistent with the defined obstacles’ criteria. The results of the 14 obstacles are listed in Table 3.
All above-mentioned obstacles were included in MLR backward stepwise elimination analyses to find out whether the obstacles are explained by any patients’ characteristics. It revealed that eight of the fourteen obstacles could be explained by some of the predictors.
3.2. Predictive Characteristics
Regression analysis revealed that eight of the fourteen obstacles could be explained by some of the predictors. We constructed models that only included predictors that significantly contributed to the model.
Model fitting information had been followed. Likelihood ratio tests for all models showed a significance level less than 0.05; Pseudo (Cox and Snell, Nagelkerke, and McFadden) revealed that 0.10–0.40 of the variation was explained. Classification tables showed that 53.2%–77.2% of cases were correctly classified in predicted response categories. All relevant models are summarized in Table 4.
4.1. Summary of the Main Findings
The current questionnaire survey was carried out in general practices and outpatient clinics across Estonia. The clinical outcomes of the present study were comparable to that of several other studies [25–28]. The percentage of participants met the target according to ADA guidelines in 27% and 59% [29, 30] of cases. The respondents on insulin therapy were younger, showed significantly higher values in HbA1c and BMI, and their disease had lasted for a longer time in comparison with the rest of the sample.
We used the Diabetes Obstacles Questionnaire to find out what obstacles they felt in coping with daily life from the perspective of patients with T2DM. Most of the respondents judged 14 statements out of 78 as being obstacles and were indifferent about the other statements. The obstacles concerned patients’ experiences of frustration and fatigue, shortage of knowledge, fear of difficulties with using insulin, and lifestyle changes, much like those already published [15, 31]. It is interesting that three of the obstacles dealt with reasons why patients could not manage physical exercises. These were no money, no time, and no enjoyment. The reason for being not delighted in exercising seems to be consistent with other research . However, 69.6% of the respondents underwent difficulties with exhaustion at almost the same rate (68.8%) as those who were considered being able to change their lifestyle.
The main interest of this study was to find predictive characteristics for obstacles (Table 4). Earlier studies had made it evident that gender and clinical indicators (BMI, HDL-c, LDL-c, BP) were connected with barriers about living with diabetes [15, 33]. In the current study, eight out of fourteen obstacles had been related to some predictive characteristic. MLR analysis revealed that age, duration of the disease, type of diabetes treatment, and BMI could be predictors for consciousness of a burden. Surprisingly, the most frequent prediction was younger age. Younger respondents recognized deeper frustration (, 95% CI: 0.91–0.99, ), uncertainty of consequences (, 95% CI: 0.87–0.96, ), acknowledged shortage of sufficient understanding about their disease (, 95% CI: 0.92–1.00, ), doubts about insulin injections (, 95% CI: 0.89–0.99, ), and fear of complications (, 95% CI: 0.88–0.98, ). Patients nearing retirement frequently perceived some burden connected with the disease. Were they, in addition to the chronic disease, overloaded with familial or work stresses?
The patients who had been ill for a longer time acknowledged that they were not capable to fit exercise into their lifestyle (, 95% CI: 1.02–1.22, ). The fear of orally treated patients for switching to insulin injections was reported in earlier studies focusing exclusively on this theme . Insulin emerged as a predictor in only two of the fourteen statements, focused on anxiety (, 95% CI: 0.05–0.41, ) and disbelief of insulin therapy (, 95% CI: 0.06–0.63, ). The respondents who used insulin did not confirm this fear, even if they suffered from diabetic complications (neuropathy, microangiopathy, diabetic foot syndrome). According to the statement that compared T1DM with T2DM, insulin and BMI were in covariance. Insulin users and nonusers experienced all other twelve obstacles similarly. Gender as a predicting factor came out only once. Women had been more critical over their knowledge about treatment (, 95% CI: 0.10–0.65, ). As we have seen, there are many obstacles about unfamiliarity with the peculiarities of the disease. The reasons for inadequate knowledge are diverse. It might take longer to get accustomed to the diagnosis and treatment options. There might have been a gap in the explanation of different treatment options from the very beginning of the disease, or else communication with other diabetes patients and diabetes associations may have been poor. The more overweight (, 95% CI: 0.14–1.45, ) a patient was, the bigger the problem was for him/her to watch his/her weight. They also had a higher diastolic BP and used diabetic medication infrequently. Diastolic BP was related to the statement referring to an inactive lifestyle (, 95% CI: 0.91–0.99, ), as well. No relationship was found between HbA1c and any studied obstacle.
4.2. Implications for Clinical Practice and Future Research
The current study elucidated that many obstacles are to some degree connected with the knowledge of the disease. Younger patients, especially, had many burdens. In any case, the GP’s role seemed to be of the highest importance in noticing a patient’s considerations, fears, and frustration arising from the disease and explaining all the aspects of the disease from the very beginning of the diagnosis. It must also be kept in mind that if there is a need to intensify treatment with insulin, then there is no reason for fear. Patients who receive insulin have found this treatment uncomplicated and easy.
Most of the participants believed that they would be able to change their lifestyle according to the advice provided by healthcare professionals. It requires a deep understanding, wisdom, and good consulting skills from the GP to encourage the capacity for building up self-efficacy and supporting a motivation for self-management [16, 34].
In future, it would be fascinating to carry out a comparable analysis using data from other countries. In addition, the sources of knowledge available to patients and the quality of information about the disease deserve further analysis.
4.3. Limitations of the Study
Methodological limitations to the study have to be acknowledged. Firstly, the findings presented here cannot be extrapolated to all patients with T2DM; they only allow making conclusions about those T2DM patients who visit their GP. Secondly, the study parameters involved only a limited number of variables. The obstacles identified could also have had associations with social indicators, such as educational level, marital status, and income.
Patients with diabetes have several burdens in everyday life. The patients picked up 14 statements that reflected their difficulties, eight of which had predictive factors. The prevalent obstacles from the patients’ standpoint were connected with frustration, uncertainty and fear of difficulties with insulin, and lifestyle changes. Younger age predicted five obstacles, and insulin nonuse and BMI two obstacles.
The Diabetes Obstacles Questionnaire (DOQ).
Scale 1—Medication Obstacles Scale.(1)I do not feel I am being prescribed the medication that is right for me(2)I do not feel I am being prescribed the medication dose that is right for me(3)I do not know what to do about taking my medication when I am feeling unwell(4)Taking insulin makes life too complicated(5)Taking insulin means my diabetes is getting worse(6)People treat insulin users differently(7)I am not in a convenient place when it is time to take my medication(8)I often forget to take my medication(9)My medication causes unwanted side effects(10)I feel resentful that I have to take my medication.
Scale 2—Self-Monitoring Obstacles Scale.(1)I find it especially hard to test when I’m busy(2)Self-monitoring makes me feel frustrated(3)Self-monitoring makes me fearful of a high reading(4)I do not feel that self-monitoring is helping me to control my diabetes(5)I find it too uncomfortable to self-monitor.
Scale 3—Obstacles of Knowledge and Beliefs Scale.(1)I do not know as much as I need to know to manage my diabetes(2)I have difficulty accessing information that is relevant to me personally(3)I have difficulty understanding the information from literature(4)I have difficulty understanding the information from healthcare professionals(5)I think that the information on diabetes is not consistent(6)I do not know as much as I need to know about the consequences of having diabetes(7)I do not know enough about the treatment for diabetes(8)I believe Type 2 diabetes is mild compared with Type 1(9)I do not know enough about the benefits of diabetes treatment for me personally(10)I do not believe the consequences of Type 2 diabetes are serious.
Scale 4—Obstacles of Diagnosis Scale.(1)The way that I was told that I had diabetes made me feel confused(2)The way that I was told that I had diabetes made me feel afraid(3)The way that I was told that I had diabetes made me feel that it was not a serious condition(4)The was that I was told that I had diabetes did not motivate me to manage my diabetes well(5)I was not given as much information as I needed about the consequences of having diabetes(6)The way that I was told that I had diabetes made me feel guilty.
Scale 5—Obstacles of Relationships with the Healthcare Professionals Scale.(1)I feel my questions about diabetes are not answered(2)I feel I am not listened to(3)I feel my judgment is not trusted in managing my diabetes(4)I am not advised at all on what to do about my diabetes(5)I am not assisted in setting realistic targets for changing my lifestyle(6)Treatment alternatives are not explained to me(7)I have not been told what to expect from my diabetes(8)I have not been told what to expect from my treatment(9)I do not feel I am part of the diabetes team(10)The good and bad aspects of my choice have not been discussed with me(11)I am not asked at all which choice I would prefer(12)Talking about my diabetes with members of the diabetes team does not make me feel better(13)Adjustments to my diabetes plan cannot be discussed(14)I feel threatened when I go for a checkup(15)I feel a sense of powerlessness when consulting with nurses(16)I feel a sense of powerlessness when consulting with doctors(17)Clinic times are inconvenient for me(18)I have to spend too much time waiting in clinics.
Scale 6—Obstacles of the Lifestyle Changes Scale.(1)My diabetic diet spoils my social life(2)I generally still feel hungry after finishing a meal(3)My diabetes has placed a strain on my personal relationships(4)There is little hope of leading a normal life when you have diabetes(5)Changes in my diet have put a strain on my family(6)I have difficulty sticking to my diet when I am away from home(7)I feel resentful that I am obliged to change my eating habits(8)I am unable to fit exercise into my lifestyle(9)I am unable to afford the cost of exercising on a regular basis(10)I haven’t found an exercise I enjoy(11)I lack the motivation to exercise(12)Weight control is a real problem for me(13)I am able to change my lifestyle in accordance with advice from healthcare professional(s).
Scale 7—Obstacles of Coping with Diabetes Scale.(1)Self-management of diabetes is difficult to maintain because diabetes complications are not immediate(2)Good control of diabetes involves a lot of sacrifice(3)I find it difficult to get into a suitable routine to cope with my treatment plan(4)I am not convinced that the treatment I receive for my diabetes is effective(5)I feel overwhelmed by the responsibility of having to take my medication(6)I feel that I would like to take a holiday from my diabetes(7)I eat something I should not rather than say I have diabetes(8)I feel that my family would like to take a holiday from my diabetes.
Scale 8—Obstacles of the Advice and Support Scale.(1)I am not convinced healthcare professionals believe the treatment I receive for my diabetes will work(2)I am told too often what I should and should not be doing to manage my diabetes(3)Constantly repeating what I should be doing to manage my diabetes makes me do it less(4)I am criticized too often about the way I manage my diabetes(5)I would manage my diabetes much better if I had more encouragement socially(6)I feel very alone with my diabetes(7)I feel I get little support from my family(8)I feel I get little support from my friends.
Conflict of Interests
The authors have declared no conflict of interests.
The authors gratefully acknowledge the patients and their GPs who agreed to participate in this study and express their gratitude to the EUROBSTACLE group. They would like to thank H. Pisarev M.S.c, Mrs. E. Jaigma, D. and Ed. Booth OP, for their time and advice. During the design and conduct of the study, the University of Tartu funded Mrs. L. Pilv as a full-time state-funded Ph.D. student. The data referred to in the current study were gathered with the support of the Estonian Science Foundation Grant no. ETF 7596.
- N. Sarwar, P. Gao, S. R. Seshasai, et al., “Diabetes mellitus, fasting blood glucose concentration, and risk of vascular disease: a collaborative meta-analysis of 102 prospective studies,” The Lancet, vol. 375, no. 9733, pp. 2215–2222, 2010.
- H. C. Gerstein, “Diabetes mellitus, fasting blood glucose concentration, and risk of vascular disease: a collaborative meta-analysis of 102 prospective studies,” The Lancet, vol. 375, no. 9733, pp. 2195–2196, 2010.
- S. R. Weingarten, J. M. Henning, E. Badamgarav et al., “Interventions used in disease management programmes for patients with chronic illness—which ones work? Meta-analysis of published reports,” British Medical Journal, vol. 325, no. 7370, pp. 925–928, 2002.
- M. Robin Dimatteo, P. J. Giordani, H. S. Lepper, and T. W. Croghan, “Patient adherence and medical treatment outcomes: a meta-analysis,” Medical Care, vol. 40, no. 9, pp. 794–811, 2002.
- J. Wens, E. Vermeire, H. Hearnshaw, A. Lindenmeyer, Y. Biot, and P. Van Royen, “Educational interventions aiming at improving adherence to treatment recommendations in type 2 diabetes. A sub-analysis of a systematic review of randomised controlled trials,” Diabetes Research and Clinical Practice, vol. 79, no. 3, pp. 377–388, 2008.
- S. L. Goff, K. M. Mazor, V. Meterko, K. Dodd, and J. Sabin, “Patients' beliefs and preferences regarding doctors' medication recommendations,” Journal of General Internal Medicine, vol. 23, no. 3, pp. 236–241, 2008.
- J. Lin, G. E. Sklar, V. M. S. Oh, and S. C. Li, “Factors affecting therapeutic compliance: a review from the patient's perspective,” Therapeutics and Clinical Risk Management, vol. 4, no. 1, pp. 269–286, 2008.
- A. Rätsep, I. Oja, R. Kalda, and M. Lember, “Family doctors' assessment of patient- and health care system-related factors contributing to non-adherence to diabetes mellitus guidelines,” Primary Care Diabetes, vol. 1, no. 2, pp. 93–97, 2007.
- M. R. DiMatteo, “Social support and patient adherence to medical treatment: a meta-analysis,” Health Psychology, vol. 23, no. 2, pp. 207–218, 2004.
- A. M. Delamater, “Improving patient adherence,” Clinical Diabetes, vol. 24, no. 2, pp. 71–77, 2006.
- L. R. Martin, S. L. Williams, K. B. Haskard, and M. R. Dimatteo, “The challenge of patient adherence,” Therapeutics and Clinical Risk Management, vol. 1, no. 3, pp. 189–199, 2005.
- M. Pibernik-Okanović, G. Roglić, M. Prašek, and Z. Metelko, “Emotional adjustment and metabolic control in newly diagnosed diabetic persons,” Diabetes Research and Clinical Practice, vol. 34, no. 2, pp. 99–105, 1996.
- E. Vermeire, H. Hearnshaw, P. Van Royen, and J. Denekens, “Patient adherence to treatment: three decades of research. A comprehensive review,” Journal of Clinical Pharmacy and Therapeutics, vol. 26, no. 5, pp. 331–342, 2001.
- H.-F. Wang and M. C. Yeh, “Psychological resistance to insulin therapy in adults with type 2 diabetes: mixed-method systematic review,” Journal of Advanced Nursing, vol. 68, no. 4, pp. 743–757, 2012.
- H. Mosnier-Pudar, G. Hochberg, E. Eschwege et al., “How do patients with type 2 diabetes perceive their disease? Insights from the French DIABASIS survey,” Diabetes and Metabolism, vol. 35, no. 3, pp. 220–227, 2009.
- J. Nagelkerk, K. Reick, and L. Meengs, “Perceived barriers and effective strategies to diabetes self-management,” Journal of Advanced Nursing, vol. 54, no. 2, pp. 151–158, 2006.
- R. Kalda, A. Rätsep, and M. Lember, “Predictors of quality of life of patients with type 2 diabetes,” Journal of Patient Preference and Adherence, vol. 2, pp. 21–26, 2008.
- H. Hearnshaw, K. Wright, J. Dale, J. Sturt, E. Vermeire, and P. Van Royen, “Development and validation of the Diabetes Obstacles Questionnaire (DOQ) to assess obstacles in living with Type 2 diabetes,” Diabetic Medicine, vol. 24, no. 8, pp. 878–882, 2007.
- M. Vandekerckhove, E. Vermeire, A. Weeren, and P. Van Royen, “Validation of the Diabetes Obstacles Questionnaire (DOQ) to assess obstacles in living with type 2 diabetes in a Belgian population,” Primary Care Diabetes, vol. 3, no. 1, pp. 43–47, 2009.
- Healthcare Commission, Managing Diabetes: Improving Services for People with Diabetes, Commission for Healthcare Audit and Inspection, London, UK, 2007.
- S. Nakar, G. Yitzhaki, R. Rosenberg, and S. Vinker, “Transition to insulin in Type 2 diabetes: family physicians' misconception of patients' fears contributes to existing barriers,” Journal of Diabetes and its Complications, vol. 21, no. 4, pp. 220–226, 2007.
- E. Vermeire, J. Wens, P. Van Royen, Y. Biot, H. Hearnshaw, and A. Lindenmeyer, “Interventions for improving adherence to treatment recommendations in people with type 2 diabetes mellitus,” Cochrane Database of Systematic Reviews, no. 2, article CD003638, 2005.
- E. Vermeire, P. Van Royen, S. Coenen, J. Wens, and J. Denekens, “The adherence of type 2 diabetes patients to their therapeutic regimens: a qualitative study from the patient's perspective,” Practical Diabetes International, vol. 20, no. 6, pp. 209–214, 2003.
- E. Vermeire, H. Hearnshaw, A. Rätsep et al., “Obstacles to adherence in living with type-2 diabetes: an international qualitative study using meta-ethnography (EUROBSTACLE),” Primary Care Diabetes, vol. 1, no. 1, pp. 25–33, 2007.
- M. Maney, C. L. Tseng, M. M. Safford, D. R. Miller, and L. M. Pogach, “Impact of self-reported patient characteristics upon assessment of glycemic control in the veterans health administration,” Diabetes Care, vol. 30, no. 2, pp. 245–251, 2007.
- R. J. MacIsaac, G. Jerums, A. J. Weekes, and M. C. Thomas, “Patterns of glycaemic control in Australian primary care (NEFRON 8),” Internal Medicine Journal, vol. 39, no. 8, pp. 512–518, 2009.
- S. J. Spann, P. A. Nutting, J. M. Galliher et al., “Management of type 2 diabetes in the primary care setting: a practice-based research network study,” Annals of Family Medicine, vol. 4, no. 1, pp. 23–31, 2006.
- A. Rätsep, R. Kalda, and M. Lember, “Meeting targets in type 2 diabetes care contributing to good glycaemic control. A cross-sectional study from a primary care setting in Estonia,” European Journal of General Practice, vol. 16, no. 2, pp. 85–91, 2010.
- I. V. Prevention, “Standards of medical care in diabetes—2011,” Diabetes Care, vol. 34, supplement 1, pp. S11–S61, 2011.
- D. Care, “Executive summary: standards of medical care in diabetes—2010,” Diabetes Care, vol. 33, supplement 1, pp. S4–S10, 2010.
- A. Rätsep, Type 2 diabetes care in family medicine [Ph.D. thesis], University of Tartu, 2009.
- N. S. Wanko, C. W. Brazier, D. Young-Rogers et al., “Exercise preferences and barriers in urban African Americans with type 2 diabetes,” Diabetes Educator, vol. 30, no. 3, pp. 502–513, 2004.
- E. Gucciardi, S. C. T. Wang, M. DeMelo, L. Amaral, and D. E. Stewart, “Characteristics of men and women with diabetes: observations during patients' initial visit to a diabetes education centre,” Canadian Family Physician, vol. 54, no. 2, pp. 219–227, 2008.
- K. E. Williams and M. J. Bond, “The roles of self-efficacy, outcome expectancies and social support in the self-care behaviours of diabetics,” Psychology, Health and Medicine, vol. 7, no. 2, pp. 127–141, 2002.