Table 3: Metabolite/degradation products of EQ detected in different organisms.

EQ metabolite/degradation productOrganism

585931.table.003a1,2-Dihydro-6-hydroxy-2,2,4-trimethylquinoline sulphateRats1
585931.table.003b1,2-Dihydro-6-hydroxy-2,2,4-trimethylquinoline glucuronideMice1
585931.table.003c1,2,3,4-Tetrahydro-3,6-dihydroxy-4-metylene-2,2-dimethylquinoline sulphateRats1
585931.table.003d1,2-Dihydro-6-ethoxy-8-hydroxy-2,2,4-trimethylquinoline glucuronideRats1  
Mice1
585931.table.003e8-(S-glutathionyl)-2,2,4-trimethylquinol-6-oneRats1  
Mice1
585931.table.003f1,2,3,4-Tetrahydro-6-ethoxy-3-hydroxy-4-(S-glutathionyl)-2,2,4-trimethylquinolineRats1  
Mice1
585931.table.003g2,6-Dihydro-2,2,4-trimethyl-6-quinolone (quinone imine (QI))Rats1  
Atlantic salmon2
585931.table.003h6-Hydroxy-2,2,4-trimethyl-1,2-dihydroquinoline (deethylated EQ (DEQ))Atlantic salmon2
585931.table.003i1,8′-Di(1,2-dihydro-6-ethoxy-2,2,4-trimethylquinoline) or 6,6′-diethoxy-2,2,2′,2′,4,4′-hexamethyl-1′,2′-dihydro-2H-1,8′-biquinoline (ethoxyquin dimer (EQDM))
*Instead of the hydrogen atom there is a methyl group, it gives methyl C-N ethoxyquin dimer,
6,6′-Diethoxy-1′,2,2,2′,2′,4,4′-heptamethyl-1′,2′-dihydro-2H-1,8′-biquinoline
Atlantic salmon2  
Pears3,4
585931.table.003jN-N Ethoxyquin dimer,
1,1′-di(1,2-dihydro-6-ethoxy-2,2,4-trimethylquinoline) or
6,6′-diethoxy-2,2,2′,2′,4,4′-hexamethyl-2H,2′H-1,1′-biquinoline
Pears3,4
585931.table.003k6-Ethoxy-1,2,2,4-tetramethyl-1,2-dihydroquinoline,
methylethoxyquin (MEQ)
Pears3,4
585931.table.003l6-Ethoxy-2,4-dimethylquinoline, dehydrodemethylethoxyquin (DHMEQ)Pears3,4
585931.table.003m6-Ethoxy-2,2,4-trimethyl-1,2,3,4-tetrahydroquinoline, dihydroethoxyquin (DHEQ)Pears3,4
585931.table.003n6-Ethoxy-2,4-dimethyl-1,2-dihydroquinoline,
demethylethoxyquin (DMEQ)
Pears3,4

Glu: glucuronide, G: glutathione, Et: ethyl group (C2H5).
1Burka et al. [21], Berdikova Bohne et al. [26], 3Gupta and Boobis [14], 4JMPR [25].