Effect of Chronic Consumption of Sweeteners on Microbiota and Immunity in the Small Intestine of Young Mice

Table 3

Hormone profile of CD1 mice supplemented with sweeteners for 6 and 12 weeks.

	CL	SUC	Splenda®	Svetia®
	Median	Median	Median	Median	p∗ Value
	pg/mL	pg/mL	pg/mL	pg/mL
6 weeks of treatment
Leptin	245	181	187	456	0.069
Resistin	5026	4490	8770	8824	0.004∗
Peptide-C	505	508	688	1260	0.009∗
TNF-α	25	32	32	27	0.314
12 weeks of treatment
Leptin	380	459	446	421	0.840
Resistin	5544	3784	4675	4788	0.149
Peptide-C	619	853	876	902	0.149
TNF-α	25	22	23	25	0.580

The values represent the Median concentration of hormones in pg/mL of mice supplemented with sweeteners. The nonparametric Kruskal-Wallis test was performed to compare the differences between the groups. The differences were considered statistically significant with p<0.05 ∗.